CD1B (CD1b molecule)

2016-10-01  

Identity

HGNC
CD1B
LOCATION
1q23.1
LOCUSID
910
ALIAS
CD1,CD1A,R1

Other Information

Locus ID:

NCBI: 910
MIM: 188360
HGNC: 1635
Ensembl: ENSG00000158485

Variants:

dbSNP: 910
ClinVar: 910
TCGA: ENSG00000158485
COSMIC: CD1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158485ENST00000368168P29016
ENSG00000158485ENST00000451207H7C0I2

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Hematopoietic cell lineageKEGGko04640
Tight junctionKEGGhsa04530
Hematopoietic cell lineageKEGGhsa04640
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
158801182005TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells.134
218078692011CD1b tetramers bind αβ T cell receptors to identify a mycobacterial glycolipid-reactive T cell repertoire in humans.61
147163132004Saposin C is required for lipid presentation by human CD1b.60
147647082004The crystal structure of human CD1b with a bound bacterial glycolipid.59
198082512009CD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice.56
119383502002Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation.55
120497212002Failure of trafficking and antigen presentation by CD1 in AP-3-deficient cells.47
168743062006Endogenous phosphatidylcholine and a long spacer ligand stabilize the lipid-binding groove of CD1b.35
220870002011Discovery of deoxyceramides and diacylglycerols as CD1b scaffold lipids among diverse groove-blocking lipids of the human CD1 system.32
266217322016Human autoreactive T cells recognize CD1b and phospholipids.32

Citation

Dessen P

CD1B (CD1b molecule)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/55986/cd1b