CD1C (CD1c molecule)

2007-02-01  

Identity

HGNC
CD1C
LOCATION
1q23.1
LOCUSID
911
ALIAS
BDCA1,CD1,CD1A,R7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 911
MIM: 188340
HGNC: 1636
Ensembl: ENSG00000158481

Variants:

dbSNP: 911
ClinVar: 911
TCGA: ENSG00000158481
COSMIC: CD1C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158481ENST00000368170P29017
ENSG00000158481ENST00000443761H0Y6Y6

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Hematopoietic cell lineageKEGGko04640
Tight junctionKEGGhsa04530
Hematopoietic cell lineageKEGGhsa04640
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

References

Pubmed IDYearTitleCitations
235301212013CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens.50
226789052012Human CD1c (BDCA-1)+ myeloid dendritic cells secrete IL-10 and display an immuno-regulatory phenotype and function in response to Escherichia coli.38
249352572014A novel self-lipid antigen targets human T cells against CD1c(+) leukemias.36
162722862005CD1a-, b-, and c-restricted TCRs recognize both self and foreign antigens.27
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
268842072016Cholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cells.26
157499182005CD1a and CD1c activate intrathyroidal T cells during Graves' disease and Hashimoto's thyroiditis.24
182872312008Inhibition of CD1 antigen presentation by human cytomegalovirus.24
194680632009CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids.22
245563952014Lipid presentation by human CD1 molecules and the diverse T cell populations that respond to them.22

Citation

Dessen P

CD1C (CD1c molecule)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45607/cd1c