CD1D (CD1d molecule)

2003-11-01  

Identity

HGNC
CD1D
LOCATION
1q23.1
LOCUSID
912
ALIAS
CD1A,R3,R3G1

Other Information

Locus ID:

NCBI: 912
MIM: 188410
HGNC: 1637
Ensembl: ENSG00000158473
IMGT/GENE-DB:

Variants:

dbSNP: 912
ClinVar: 912
TCGA: ENSG00000158473
COSMIC: CD1D

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158473ENST00000368171P15813

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Hematopoietic cell lineageKEGGko04640
Tight junctionKEGGhsa04530
Hematopoietic cell lineageKEGGhsa04640
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
93744631997CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides.718
175815922007CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor.224
160070902005The crystal structure of human CD1d with and without alpha-galactosylceramide.150
152431592004Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells.116
240766362013CD1d-lipid antigen recognition by the γδ TCR.97
156650862005Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells.86
147163122004Saposins facilitate CD1d-restricted presentation of an exogenous lipid antigen to T cells.77
185351992008Inflammation-associated lysophospholipids as ligands for CD1d-restricted T cells in human cancer.77
194151162009Determination of cellular lipids bound to human CD1d molecules.77
228291342012The majority of CD1d-sulfatide-specific T cells in human blood use a semiinvariant Vδ1 TCR.76

Citation

Dessen P

CD1D (CD1d molecule)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/970/cd1d