CD226 (CD226 molecule)

2007-02-01  

Identity

HGNC
LOCATION
18q22.2
LOCUSID
ALIAS
DNAM-1,DNAM1,PTA1,TLiSA1
FUSION GENES

Other Information

Locus ID:

NCBI: 10666
MIM: 605397
HGNC: 16961
Ensembl: ENSG00000150637

Variants:

dbSNP: 10666
ClinVar: 10666
TCGA: ENSG00000150637
COSMIC: CD226

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000150637ENST00000280200Q15762
ENSG00000150637ENST00000577287J3QR77
ENSG00000150637ENST00000578928J3QKM7
ENSG00000150637ENST00000579496J3QQW1
ENSG00000150637ENST00000580335J3QL19
ENSG00000150637ENST00000581982J3QR77
ENSG00000150637ENST00000582621Q15762
ENSG00000150637ENST00000583955J3QRQ4

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
129130962003Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule.237
254658002014The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function.179
178756812007The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer cell-mediated killing of myeloma cells.103
224276442012The TIGIT/CD226 axis regulates human T cell function.84
198015172009Primary human tumor cells expressing CD155 impair tumor targeting by down-regulating DNAM-1 on NK cells.74
189719392009CD226 Gly307Ser association with multiple autoimmune diseases.70
189719392009CD226 Gly307Ser association with multiple autoimmune diseases.70
151365892004DNAM-1 and PVR regulate monocyte migration through endothelial junctions.67
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
146762972003CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation.54

Citation

Dessen P

CD226 (CD226 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46470/cd226