CD244 (CD244 molecule)

2007-02-01  

Identity

HGNC
LOCATION
1q23.3
LOCUSID
ALIAS
2B4,NAIL,NKR2B4,Nmrk,SLAMF4
FUSION GENES

Other Information

Locus ID:

NCBI: 51744
MIM: 605554
HGNC: 18171
Ensembl: ENSG00000122223

Variants:

dbSNP: 51744
ClinVar: 51744
TCGA: ENSG00000122223
COSMIC: CD244

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122223ENST00000322302Q9BZW8
ENSG00000122223ENST00000368033Q9BZW8
ENSG00000122223ENST00000368034Q9BZW8
ENSG00000122223ENST00000492063Q9BZW8

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Natural killer cell mediated cytotoxicityKEGGko04650
Natural killer cell mediated cytotoxicityKEGGhsa04650
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733

References

Pubmed IDYearTitleCitations
210640322010The immunoregulatory role of CD244 in chronic hepatitis B infection and its inhibitory potential on virus-specific CD8+ T-cell function.74
157137982005Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244).65
185232812008Molecular basis of the dual functions of 2B4 (CD244).64
224388122012TGF-β1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
232252182013Monocyte/macrophage-elicited natural killer cell dysfunction in hepatocellular carcinoma is mediated by CD48/2B4 interactions.60
1963846720092B4 (CD244) signaling by recombinant antigen-specific chimeric receptors costimulates natural killer cell activation to leukemia and neuroblastoma cells.55
156775582005SAP controls the cytolytic activity of CD8+ T cells against EBV-infected cells.48
216255892011Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cells.48
261505042015Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+ T-cell immune responses in tuberculosis infection.47

Citation

Dessen P

CD244 (CD244 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45803/cd244