CD33 (CD33 molecule)

2003-11-01  

Identity

HGNC
LOCATION
19q13.41
LOCUSID
ALIAS
SIGLEC-3,SIGLEC3,p67
FUSION GENES

Other Information

Locus ID:

NCBI: 945
MIM: 159590
HGNC: 1659
Ensembl: ENSG00000105383

Variants:

dbSNP: 945
ClinVar: 945
TCGA: ENSG00000105383
COSMIC: CD33

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105383ENST00000262262P20138
ENSG00000105383ENST00000262262Q546G0
ENSG00000105383ENST00000391796P20138
ENSG00000105383ENST00000421133P20138
ENSG00000105383ENST00000436584B4DF51

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Hematopoietic cell lineageKEGGko04640
Hematopoietic cell lineageKEGGhsa04640
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164749431gemtuzumab ozogamicinChemicalClinicalAnnotation, VariantAnnotationassociatedPD
PA166123207overall survivalDiseaseVariantAnnotationassociatedPD
PA444760Leukemia, Myeloid, AcuteDiseaseClinicalAnnotation, VariantAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
214608412011Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.716
214608402011Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.685
236236982013Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta.260
237081422013CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology.163
195721482010Population alterations of L-arginase- and inducible nitric oxide synthase-expressed CD11b+/CD14⁻/CD15+/CD33+ myeloid-derived suppressor cells and CD8+ T lymphocytes in patients with advanced-stage non-small cell lung cancer.103
239463902013CD33 Alzheimer's risk-altering polymorphism, CD33 expression, and exon 2 splicing.74
246529872014CD16xCD33 bispecific killer cell engager (BiKE) activates NK cells against primary MDS and MDSC CD33+ targets.74
268470562016IL15 Trispecific Killer Engagers (TriKE) Make Natural Killer Cells Specific to CD33+ Targets While Also Inducing Persistence, In Vivo Expansion, and Enhanced Function.66
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
249274072014Distribution and levels of cell surface expression of CD33 and CD123 in acute myeloid leukemia.52

Citation

Dessen P

CD33 (CD33 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/974/cd33