CD36 (CD36 molecule)

2003-11-01 Affiliation

Identity

HGNC

CD36

LOCATION

7q21.11

LOCUSID

948

ALIAS

BDPLT10,CHDS7,FAT,GP3B,GP4,GPIV,PASIV,SCARB3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 948
MIM: 173510
HGNC: 1663
Ensembl: ENSG00000135218

Variants:

dbSNP: 948
ClinVar: 948
TCGA: ENSG00000135218
COSMIC: CD36

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000135218	ENST00000309881	P16671
ENSG00000135218	ENST00000309881	A4D1B1
ENSG00000135218	ENST00000394788	P16671
ENSG00000135218	ENST00000394788	A4D1B1
ENSG00000135218	ENST00000413265	E7EX47
ENSG00000135218	ENST00000419819	E7EU05
ENSG00000135218	ENST00000426978	E7EWI4
ENSG00000135218	ENST00000428497	E9PC45
ENSG00000135218	ENST00000432207	P16671
ENSG00000135218	ENST00000432207	A4D1B1
ENSG00000135218	ENST00000433696	P16671
ENSG00000135218	ENST00000435819	P16671
ENSG00000135218	ENST00000435819	A4D1B1
ENSG00000135218	ENST00000436384	E9PC45
ENSG00000135218	ENST00000438020	E7ERZ9
ENSG00000135218	ENST00000441034	E7EVU1
ENSG00000135218	ENST00000447544	P16671
ENSG00000135218	ENST00000447544	A4D1B1
ENSG00000135218	ENST00000482059	E9PJX8
ENSG00000135218	ENST00000488048	H0YEE7
ENSG00000135218	ENST00000534394	E9PLT1
ENSG00000135218	ENST00000538969	P16671
ENSG00000135218	ENST00000544133	P16671

Expression (GTEx)

100

200

300

400

500

600

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
PPAR signaling pathway	KEGG	ko03320
ECM-receptor interaction	KEGG	ko04512
Hematopoietic cell lineage	KEGG	ko04640
Adipocytokine signaling pathway	KEGG	ko04920
PPAR signaling pathway	KEGG	hsa03320
ECM-receptor interaction	KEGG	hsa04512
Hematopoietic cell lineage	KEGG	hsa04640
Adipocytokine signaling pathway	KEGG	hsa04920
Malaria	KEGG	ko05144
Malaria	KEGG	hsa05144
Phagosome	KEGG	ko04145
Phagosome	KEGG	hsa04145
Fat digestion and absorption	KEGG	ko04975
Fat digestion and absorption	KEGG	hsa04975
AMPK signaling pathway	KEGG	hsa04152
AMPK signaling pathway	KEGG	ko04152
Disease	REACTOME	R-HSA-1643685
Diseases of Immune System	REACTOME	R-HSA-5260271
Diseases associated with the TLR signaling cascade	REACTOME	R-HSA-5602358
IRAK4 deficiency (TLR2/4)	REACTOME	R-HSA-5603041
MyD88 deficiency (TLR2/4)	REACTOME	R-HSA-5602498
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing-Cross presentation	REACTOME	R-HSA-1236975
Cross-presentation of particulate exogenous antigens (phagosomes)	REACTOME	R-HSA-1236973
ER-Phagosome pathway	REACTOME	R-HSA-1236974
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Toll Like Receptor 4 (TLR4) Cascade	REACTOME	R-HSA-166016
Activated TLR4 signalling	REACTOME	R-HSA-166054
MyD88:Mal cascade initiated on plasma membrane	REACTOME	R-HSA-166058
Toll Like Receptor 2 (TLR2) Cascade	REACTOME	R-HSA-181438
Toll Like Receptor TLR1:TLR2 Cascade	REACTOME	R-HSA-168179
Toll Like Receptor TLR6:TLR2 Cascade	REACTOME	R-HSA-168188
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Response to elevated platelet cytosolic Ca2+	REACTOME	R-HSA-76005
Platelet degranulation	REACTOME	R-HSA-114608
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Binding and Uptake of Ligands by Scavenger Receptors	REACTOME	R-HSA-2173782
Scavenging by Class B Receptors	REACTOME	R-HSA-3000471
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolism	REACTOME	R-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	REACTOME	R-HSA-400206
PPARA activates gene expression	REACTOME	R-HSA-1989781
Developmental Biology	REACTOME	R-HSA-1266738
Transcriptional regulation of white adipocyte differentiation	REACTOME	R-HSA-381340
Insulin resistance	KEGG	hsa04931
Regulation of TLR by endogenous ligand	REACTOME	R-HSA-5686938
Neutrophil degranulation	REACTOME	R-HSA-6798695
Interleukin-4 and 13 signaling	REACTOME	R-HSA-6785807

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA26716	COL3A1	Gene	Pathway	associated	20938371
PA26717	COL4A1	Gene	Pathway	associated	20938371
PA26718	COL4A2	Gene	Pathway	associated	20938371
PA33384	PLCB1	Gene	Pathway	associated	20938371
PA33393	PLCG2	Gene	Pathway	associated	20938371
PA35041	COL1A1	Gene	Pathway	associated	20938371
PA35042	COL1A2	Gene	Pathway	associated	20938371

References

Pubmed ID	Year	Title	Citations
20037584	2010	CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.	466
27974793	2017	Targeting metastasis-initiating cells through the fatty acid receptor CD36.	208
16276419	2005	CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions.	160
16880211	2006	Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting.	150
12105195	2002	Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36.	140
19065049	2009	CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima.	137
16556603	2006	A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway.	123
21270117	2011	Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C.	99
15132977	2004	Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36.	93
19185504	2009	Cellular fatty acid uptake: a pathway under construction.	93

Citation

Dessen P

CD36 (CD36 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/976/cd36