CD3D (CD3d molecule)

2011-10-01  

Identity

HGNC
LOCATION
11q23.3
LOCUSID
ALIAS
CD3-DELTA,IMD19,T3D
FUSION GENES

Other Information

Locus ID:

NCBI: 915
MIM: 186790
HGNC: 1673
Ensembl: ENSG00000167286

Variants:

dbSNP: 915
ClinVar: 915
TCGA: ENSG00000167286
COSMIC: CD3D

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167286ENST00000300692P04234
ENSG00000167286ENST00000300692B0YIY4
ENSG00000167286ENST00000392884P04234
ENSG00000167286ENST00000529594E9PMT5
ENSG00000167286ENST00000534687H0YE18

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Hematopoietic cell lineageKEGGko04640
T cell receptor signaling pathwayKEGGko04660
Primary immunodeficiencyKEGGko05340
Hematopoietic cell lineageKEGGhsa04640
T cell receptor signaling pathwayKEGGhsa04660
Primary immunodeficiencyKEGGhsa05340
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
MeaslesKEGGko05162
MeaslesKEGGhsa05162
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
TCR signalingREACTOMER-HSA-202403
Phosphorylation of CD3 and TCR zeta chainsREACTOMER-HSA-202427
Translocation of ZAP-70 to Immunological synapseREACTOMER-HSA-202430
Generation of second messenger moleculesREACTOMER-HSA-202433
Downstream TCR signalingREACTOMER-HSA-202424
Costimulation by the CD28 familyREACTOMER-HSA-388841
PD-1 signalingREACTOMER-HSA-389948
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
171760952006Lipid-binding activity of intrinsically unstructured cytoplasmic domains of multichain immune recognition receptor signaling subunits.52
219847022011Epidermal CCR6+ γδ T cells are major producers of IL-22 and IL-17 in a murine model of psoriasiform dermatitis.44
146028802003Effect of CD3delta deficiency on maturation of alpha/beta and gamma/delta T-cell lineages in severe combined immunodeficiency.41
155460022004Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3.41
155342022004Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment.40
254224322014Molecular architecture of the αβ T cell receptor-CD3 complex.37
216703112011Stimulated γδ T cells increase the in vivo efficacy of trastuzumab in HER-2+ breast cancer.35
190566902009An early decrease in Notch activation is required for human TCR-alphabeta lineage differentiation at the expense of TCR-gammadelta T cells.33
205115572010NKG2D costimulates human V gamma 9V delta 2 T cell antitumor cytotoxicity through protein kinase C theta-dependent modulation of early TCR-induced calcium and transduction signals.31
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27

Citation

Dessen P

CD3D (CD3d molecule)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52453/cd3d