CD70 (CD70 molecule)

2003-06-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
CD27-L,CD27L,CD27LG,LPFS3,TNFSF7,TNLG8A
FUSION GENES

Other Information

Locus ID:

NCBI: 970
MIM: 602840
HGNC: 11937
Ensembl: ENSG00000125726

Variants:

dbSNP: 970
ClinVar: 970
TCGA: ENSG00000125726
COSMIC: CD70

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125726ENST00000245903P32970
ENSG00000125726ENST00000245903A0A0U5JA32
ENSG00000125726ENST00000597430M0QZW2

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNFs bind their physiological receptorsREACTOMER-HSA-5669034

References

Pubmed IDYearTitleCitations
167514202006Modulation by IL-2 of CD70 and CD27 expression on CD8+ T cells: importance for the therapeutic effectiveness of cell transfer immunotherapy.69
213041032011T cells redirected against CD70 for the immunotherapy of CD70-positive malignancies.52
119806542002Identification of CD70-mediated apoptosis of immune effector cells as a novel immune escape pathway of human glioblastoma.50
176152912007CD70+ non-Hodgkin lymphoma B cells induce Foxp3 expression and regulatory function in intratumoral CD4+CD25 T cells.48
206993612011Role of CD27/CD70 pathway of activation in immunity and tolerance.46
175483422007CD27-CD70 interactions sensitise naive CD4+ T cells for IL-12-induced Th1 cell development.37
201390962010Plasmacytoid dendritic cells regulate B-cell growth and differentiation via CD70.37
190294462009Prostaglandin E(2) enhances T-cell proliferation by inducing the costimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cells.36
280118642017Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency.34
235765052013CD27-CD70 costimulation controls T cell immunity during acute and persistent cytomegalovirus infection.32

Citation

Dessen P

CD70 (CD70 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42643/cd70