Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CD70 (CD70 molecule)

Identity

Alias (NCBI)CD27-L
CD27L
CD27LG
LPFS3
TNFSF7
TNLG8A
HGNC (Hugo) CD70
HGNC Alias symbCD27L
HGNC Previous nameCD27LG
 TNFSF7
HGNC Previous nametumor necrosis factor (ligand) superfamily, member 7
LocusID (NCBI) 970
Atlas_Id 42643
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 6581648 and ends at 6591150 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KHSRP (19p13.3) / CD70 (19p13.3)KHSRP 19p13.3 / CD70 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Head and Neck: Thymus: Thymoma: an overview
KHSRP/CD70 (19p13)

External links

Nomenclature
HGNC (Hugo)CD70   11937
Cards
Entrez_Gene (NCBI)CD70    CD70 molecule
AliasesCD27-L; CD27L; CD27LG; LPFS3; 
TNFSF7; TNLG8A
GeneCards (Weizmann)CD70
Ensembl hg19 (Hinxton)ENSG00000125726 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125726 [Gene_View]  ENSG00000125726 [Sequence]  chr19:6581648-6591150 [Contig_View]  CD70 [Vega]
ICGC DataPortalENSG00000125726
TCGA cBioPortalCD70
AceView (NCBI)CD70
Genatlas (Paris)CD70
SOURCE (Princeton)CD70
Genetics Home Reference (NIH)CD70
Genomic and cartography
GoldenPath hg38 (UCSC)CD70  -     chr19:6581648-6591150 -  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CD70  -     19p13.3   [Description]    (hg19-Feb_2009)
GoldenPathCD70 - 19p13.3 [CytoView hg19]  CD70 - 19p13.3 [CytoView hg38]
ImmunoBaseENSG00000125726
genome Data Viewer NCBICD70 [Mapview hg19]  
OMIM602840   618261   
Gene and transcription
Genbank (Entrez)AK298467 BC000725 BT007211 L08096 LN874328
RefSeq transcript (Entrez)NM_001252 NM_001330332
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CD70
Alternative Splicing GalleryENSG00000125726
Gene ExpressionCD70 [ NCBI-GEO ]   CD70 [ EBI - ARRAY_EXPRESS ]   CD70 [ SEEK ]   CD70 [ MEM ]
Gene Expression Viewer (FireBrowse)CD70 [ Firebrowse - Broad ]
GenevisibleExpression of CD70 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)970
GTEX Portal (Tissue expression)CD70
Human Protein AtlasENSG00000125726-CD70 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP32970   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP32970  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP32970
Splice isoforms : SwissVarP32970
PhosPhoSitePlusP32970
Domaine pattern : Prosite (Expaxy)TNF_1 (PS00251)    TNF_2 (PS50049)   
Domains : Interpro (EBI)CD70    TNF_CS    TNF_dom    Tumour_necrosis_fac-like_dom   
Domain families : Pfam (Sanger)TNF (PF00229)   
Domain families : Pfam (NCBI)pfam00229   
Domain families : Smart (EMBL)TNF (SM00207)  
Conserved Domain (NCBI)CD70
Blocks (Seattle)CD70
SuperfamilyP32970
Human Protein Atlas [tissue]ENSG00000125726-CD70 [tissue]
Peptide AtlasP32970
HPRD18515
IPIIPI00031713   IPI00909266   
Protein Interaction databases
DIP (DOE-UCLA)P32970
IntAct (EBI)P32970
BioGRIDCD70
STRING (EMBL)CD70
ZODIACCD70
Ontologies - Pathways
QuickGOP32970
Ontology : AmiGOprotease binding  T cell mediated immunity  signaling receptor binding  cytokine activity  tumor necrosis factor receptor binding  protein binding  plasma membrane  plasma membrane  plasma membrane  integral component of plasma membrane  signal transduction  cell-cell signaling  B cell mediated immunity  tumor necrosis factor-mediated signaling pathway  B cell proliferation  positive regulation of T cell proliferation  extracellular exosome  extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIprotease binding  T cell mediated immunity  signaling receptor binding  cytokine activity  tumor necrosis factor receptor binding  protein binding  plasma membrane  plasma membrane  plasma membrane  integral component of plasma membrane  signal transduction  cell-cell signaling  B cell mediated immunity  tumor necrosis factor-mediated signaling pathway  B cell proliferation  positive regulation of T cell proliferation  extracellular exosome  extrinsic apoptotic signaling pathway  
Pathways : KEGGCytokine-cytokine receptor interaction   
NDEx NetworkCD70
Atlas of Cancer Signalling NetworkCD70
Wikipedia pathwaysCD70
Orthology - Evolution
OrthoDB970
GeneTree (enSembl)ENSG00000125726
Phylogenetic Trees/Animal Genes : TreeFamCD70
HOGENOMP32970
Homologs : HomoloGeneCD70
Homology/Alignments : Family Browser (UCSC)CD70
Gene fusions - Rearrangements
Fusion : MitelmanKHSRP/CD70 [19p13.3/19p13.3]  
Fusion PortalKHSRP 19p13.3 CD70 19p13.3 BRCA
Fusion : QuiverCD70
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCD70 [hg38]
dbVarCD70
ClinVarCD70
MonarchCD70
1000_GenomesCD70 
Exome Variant ServerCD70
GNOMAD BrowserENSG00000125726
Varsome BrowserCD70
Genomic Variants (DGV)CD70 [DGVbeta]
DECIPHERCD70 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCD70 
Mutations
ICGC Data PortalCD70 
TCGA Data PortalCD70 
Broad Tumor PortalCD70
OASIS PortalCD70 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCD70  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCD70
Mutations and Diseases : HGMDCD70
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CD70
DgiDB (Drug Gene Interaction Database)CD70
DoCM (Curated mutations)CD70 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CD70 (select a term)
intoGenCD70
Cancer3DCD70(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602840    618261   
Orphanet
DisGeNETCD70
MedgenCD70
Genetic Testing Registry CD70
NextProtP32970 [Medical]
GENETestsCD70
Target ValidationCD70
Huge Navigator CD70 [HugePedia]
ClinGenCD70
Clinical trials, drugs, therapy
MyCancerGenomeCD70
Protein Interactions : CTD
Pharm GKB GenePA36627
PharosP32970
Clinical trialCD70
Miscellaneous
canSAR (ICR)CD70 (select the gene name)
HarmonizomeCD70
DataMed IndexCD70
Probes
Litterature
PubMed95 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCD70
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jan 1 18:09:08 CET 2021
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