CD72 (CD72 molecule)

2003-11-01  

Identity

HGNC
CD72
LOCATION
9p13.3
LOCUSID
971
ALIAS
CD72b,LYB2

Other Information

Locus ID:

NCBI: 971
MIM: 107272
HGNC: 1696
Ensembl: ENSG00000137101

Variants:

dbSNP: 971
ClinVar: 971
TCGA: ENSG00000137101
COSMIC: CD72

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137101ENST00000259633P21854
ENSG00000137101ENST00000259633Q5TLG3
ENSG00000137101ENST00000378430Q5T4Q7
ENSG00000137101ENST00000378431Q5T4Q8
ENSG00000137101ENST00000396757P21854
ENSG00000137101ENST00000612238A0A087X0Y7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
B cell receptor signaling pathwayKEGGko04662
B cell receptor signaling pathwayKEGGhsa04662
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
Other semaphorin interactionsREACTOMER-HSA-416700

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
201009312010CD72 negatively regulates KIT-mediated responses in human mast cells.11
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
154591832004CD72 polymorphisms associated with alternative splicing modify susceptibility to human systemic lupus erythematosus through epistatic interaction with FCGR2B.9
154591832004CD72 polymorphisms associated with alternative splicing modify susceptibility to human systemic lupus erythematosus through epistatic interaction with FCGR2B.9
160473372005CD72-mediated suppression of human naive B cell differentiation by down-regulating X-box binding protein 1.9
244610792014A regulatory role for CD72 expression on B cells in systemic lupus erythematosus.8
177861902007CD100 on NK cells enhance IFNgamma secretion and killing of target cells expressing CD72.6
171215832006Increased mutations of CD72 transcript in B-lymphocytes from adolescent patients with systemic lupus erythematosus.5

Citation

Dessen P

CD72 (CD72 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/990/cd72