CD8A (CD8a molecule)

2003-05-01  

Identity

HGNC
LOCATION
2p11.2
LOCUSID
ALIAS
CD8,Leu2,p32
FUSION GENES

Other Information

Locus ID:

NCBI: 925
MIM: 186910
HGNC: 1706
Ensembl: ENSG00000153563

Variants:

dbSNP: 925
ClinVar: 925
TCGA: ENSG00000153563
COSMIC: CD8A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153563ENST00000283635P01732
ENSG00000153563ENST00000352580P01732
ENSG00000153563ENST00000409511P01732
ENSG00000153563ENST00000409781B8ZZZ4

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Antigen processing and presentationKEGGko04612
Hematopoietic cell lineageKEGGko04640
T cell receptor signaling pathwayKEGGko04660
Primary immunodeficiencyKEGGko05340
Cell adhesion molecules (CAMs)KEGGhsa04514
Antigen processing and presentationKEGGhsa04612
Hematopoietic cell lineageKEGGhsa04640
T cell receptor signaling pathwayKEGGhsa04660
Primary immunodeficiencyKEGGhsa05340
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
181562042008Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis.320
214300662011Anti-TIM3 antibody promotes T cell IFN-γ-mediated antitumor immunity and suppresses established tumors.183
184832772008Transforming growth factor beta subverts the immune system into directly promoting tumor growth through interleukin-17.107
159759222005Cellular p32 recruits cytomegalovirus kinase pUL97 to redistribute the nuclear lamina.80
219489822011Cutting edge: expression of XCR1 defines mouse lymphoid-tissue resident and migratory dendritic cells of the CD8α+ type.76
183985082008Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection.68
186503842008Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses.64
186950052008Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection.64
125948412003Soluble HLA-A,-B,-C and -G molecules induce apoptosis in T and NK CD8+ cells and inhibit cytotoxic T cell activity through CD8 ligation.54
212579702011CD4 and CD8 T cell immune activation during chronic HIV infection: roles of homeostasis, HIV, type I IFN, and IL-7.54

Citation

Dessen P

CD8A (CD8a molecule)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/993/cd8a