CD8B (CD8b molecule)

2003-05-01  

Identity

HGNC
LOCATION
2p11.2
LOCUSID
ALIAS
CD8B1,LEU2,LY3,LYT3,P37
FUSION GENES

Other Information

Locus ID:

NCBI: 926
MIM: 186730
HGNC: 1707
Ensembl: ENSG00000172116

Variants:

dbSNP: 926
ClinVar: 926
TCGA: ENSG00000172116
COSMIC: CD8B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172116ENST00000331469P10966
ENSG00000172116ENST00000349455P10966
ENSG00000172116ENST00000390655P10966
ENSG00000172116ENST00000393759P10966
ENSG00000172116ENST00000393761P10966
ENSG00000172116ENST00000431506E9PD41

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Antigen processing and presentationKEGGko04612
Hematopoietic cell lineageKEGGko04640
T cell receptor signaling pathwayKEGGko04660
Primary immunodeficiencyKEGGko05340
Cell adhesion molecules (CAMs)KEGGhsa04514
Antigen processing and presentationKEGGhsa04612
Hematopoietic cell lineageKEGGhsa04640
T cell receptor signaling pathwayKEGGhsa04660
Primary immunodeficiencyKEGGhsa05340
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
Host Interactions of HIV factorsREACTOMER-HSA-162909
The role of Nef in HIV-1 replication and disease pathogenesisREACTOMER-HSA-164952
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adaptersREACTOMER-HSA-164938
Nef Mediated CD8 Down-regulationREACTOMER-HSA-182218
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
197686962009Novel CD8+ Treg suppress EAE by TGF-beta- and IFN-gamma-dependent mechanisms.38
242971792014cAMP responsive element modulator (CREM) α mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells.18
240479022013cAMP-responsive element modulator α (CREMα) trans-represses the transmembrane glycoprotein CD8 and contributes to the generation of CD3+CD4-CD8- T cells in health and disease.13
220130622012Down-modulation of CD8αβ is a fundamental activity of primate lentiviral Nef proteins.12
119375472002Identification of a candidate regulatory region in the human CD8 gene complex by colocalization of DNase I hypersensitive sites and matrix attachment regions which bind SATB1 and GATA-3.10
184907432008Differential expression of the human CD8beta splice variants and regulation of the M-2 isoform by ubiquitination.7
219542832011The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells.6
273465742016CD8 down-regulation on cytotoxic T lymphocytes of patients with endometrioid endometrial carcinomas.3
289769842017Mycoplasma-associated multidrug resistance of hepatocarcinoma cells requires the interaction of P37 and Annexin A2.3

Citation

Dessen P

CD8B (CD8b molecule)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/994/cd8b