CDC42EP3 (CDC42 effector protein 3)

2007-04-01  

Identity

HGNC
CDC42EP3
LOCATION
2p22.2
LOCUSID
10602
ALIAS
BORG2,CEP3,UB1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10602
MIM: 606133
HGNC: 16943
Ensembl: ENSG00000163171

Variants:

dbSNP: 10602
ClinVar: 10602
TCGA: ENSG00000163171
COSMIC: CDC42EP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163171ENST00000295324Q9UKI2
ENSG00000163171ENST00000422687C9JKW5
ENSG00000163171ENST00000453555C9J7F7
ENSG00000163171ENST00000457889C9JEZ4
ENSG00000163171ENST00000611976Q9UKI2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK6/MAPK4 signalingREACTOMER-HSA-5687128

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
349988122022Deduction of CDC42EP3 suppress development and progression of osteosarcoma.2
353656222022CDC42EP3 promotes glioma progression via regulation of CCND1.10
349988122022Deduction of CDC42EP3 suppress development and progression of osteosarcoma.2
353656222022CDC42EP3 promotes glioma progression via regulation of CCND1.10
341112802021CDC42EP3 is a key promoter involved in the development and progression of gastric cancer.4
341112802021CDC42EP3 is a key promoter involved in the development and progression of gastric cancer.4
327392122020Overactivated Cdc42 acts through Cdc42EP3/Borg2 and NCK to trigger DNA damage response signaling and sensitize cells to DNA-damaging agents.5
327392122020Overactivated Cdc42 acts through Cdc42EP3/Borg2 and NCK to trigger DNA damage response signaling and sensitize cells to DNA-damaging agents.5
272482912017Cdc42 regulates Cdc42EP3 function in cancer-associated fibroblasts.16
272482912017Cdc42 regulates Cdc42EP3 function in cancer-associated fibroblasts.16
279136812016The Borg family of Cdc42 effector proteins Cdc42EP1-5.25
279136812016The Borg family of Cdc42 effector proteins Cdc42EP1-5.25
203853742010Altered cortical CDC42 signaling pathways in schizophrenia: implications for dendritic spine deficits.58
203853742010Altered cortical CDC42 signaling pathways in schizophrenia: implications for dendritic spine deficits.58

Citation

Dessen P

CDC42EP3 (CDC42 effector protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47344/cdc42ep3