CDCA2 (cell division cycle associated 2)

2013-09-01  

Identity

HGNC
CDCA2
LOCATION
8p21.2
LOCUSID
157313
ALIAS
PPP1R81,Repo-Man
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 157313
MIM: 618785
HGNC: 14623
Ensembl: ENSG00000184661

Variants:

dbSNP: 157313
ClinVar: 157313
TCGA: ENSG00000184661
COSMIC: CDCA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184661ENST00000330560Q69YH5
ENSG00000184661ENST00000380665E9PEI0

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
164928072006Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability.103
215141572011PP1/Repo-man dephosphorylates mitotic histone H3 at T3 and regulates chromosomal aurora B targeting.77
218203632011Repo-Man coordinates chromosomal reorganization with nuclear envelope reassembly during mitotic exit.69
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
201885552010Repo-man controls a protein phosphatase 1-dependent threshold for DNA damage checkpoint activation.42
228017822012Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores.34
237466402013Aurora B defines its own chromosomal targeting by opposing the recruitment of the phosphatase scaffold Repo-Man.33
279985402016Expanding the PP2A Interactome by Defining a B56-Specific SLiM.27
234185642013Overexpression of CDCA2 in human squamous cell carcinoma: correlation with prevention of G1 phase arrest and apoptosis.21
275722602016The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism.20

Citation

Dessen P

CDCA2 (cell division cycle associated 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-09-01

Online version: http://atlasgeneticsoncology.org/gene/53500/cdca2