CDCA5 (cell division cycle associated 5)

2010-08-01  

Identity

HGNC
LOCATION
11q13.1
LOCUSID
ALIAS
SORORIN
FUSION GENES

Other Information

Locus ID:

NCBI: 113130
MIM: 609374
HGNC: 14626
Ensembl: ENSG00000146670

Variants:

dbSNP: 113130
ClinVar: 113130
TCGA: ENSG00000146670
COSMIC: CDCA5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146670ENST00000275517Q96FF9
ENSG00000146670ENST00000275517A0A024R5D6
ENSG00000146670ENST00000404147B5MBX0
ENSG00000146670ENST00000524733H0YCL8
ENSG00000146670ENST00000525464H0YCT9
ENSG00000146670ENST00000527430H0YCZ9
ENSG00000146670ENST00000529290H0YCR8

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
S PhaseREACTOMER-HSA-69242
Establishment of Sister Chromatid CohesionREACTOMER-HSA-2468052
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
173497912007Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
228335682012Interplay between MEK-ERK signaling, cyclin D1, and cyclin-dependent kinase 5 regulates cell cycle reentry and apoptosis of neurons.34
252573092014SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs.24
205510602010Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis.23
219875892011Interaction of Sororin protein with polo-like kinase 1 mediates resolution of chromosomal arm cohesion.21
264976782016Therapeutic potential of targeting cell division cycle associated 5 for oral squamous cell carcinoma.14
250927912014Sororin pre-mRNA splicing is required for proper sister chromatid cohesion in human cells.13
269516382016Sororin loads to the synaptonemal complex central region independently of meiotic cohesin complexes.13
211154942011A conserved motif at the C terminus of sororin is required for sister chromatid cohesion.11

Citation

Dessen P

CDCA5 (cell division cycle associated 5)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51637/cdca5