CDCA7 (cell division cycle associated 7)

2004-05-01  

Identity

HGNC
LOCATION
2q31.1
LOCUSID
ALIAS
ICF3,JPO1
FUSION GENES

Other Information

Locus ID:

NCBI: 83879
MIM: 609937
HGNC: 14628
Ensembl: ENSG00000144354

Variants:

dbSNP: 83879
ClinVar: 83879
TCGA: ENSG00000144354
COSMIC: CDCA7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144354ENST00000306721Q9BWT1
ENSG00000144354ENST00000347703Q9BWT1
ENSG00000144354ENST00000410019Q9BWT1
ENSG00000144354ENST00000410101Q9BWT1
ENSG00000144354ENST00000435616F8WBA7

Expression (GTEx)

0
10
20
30
40
50
60

References

Pubmed IDYearTitleCitations
262163462015Mutations in CDCA7 and HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome.34
293394832018HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome.21
240294272013Chromosome 2q31.1 associates with ESRD in women with type 1 diabetes.20
231662942013The MYC-associated protein CDCA7 is phosphorylated by AKT to regulate MYC-dependent apoptosis and transformation.19
165807492006JPO1/CDCA7, a novel transcription factor E2F1-induced protein, possesses intrinsic transcriptional regulator activity.13
253857552014Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence.11
274662022016Converging disease genes in ICF syndrome: ZBTB24 controls expression of CDCA7 in mammals.11
296598382018Comparative methylome analysis of ICF patients identifies heterochromatin loci that require ZBTB24, CDCA7 and HELLS for their methylated state.11
301518902018Overexpression of CDCA7 predicts poor prognosis and induces EZH2-mediated progression of triple-negative breast cancer.8
303074082019CDCA7 and HELLS mutations undermine nonhomologous end joining in centromeric instability syndrome.7

Citation

Dessen P

CDCA7 (cell division cycle associated 7)

Atlas Genet Cytogenet Oncol Haematol. 2004-05-01

Online version: http://atlasgeneticsoncology.org/gene/421/cdca7