Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CDH11 (cadherin 11)

Identity

Alias_namescadherin 11, type 2, OB-cadherin (osteoblast)
Alias_symbol (synonym)OB
CAD11
Other aliasCDHOB
ESWS
OSF-4
HGNC (Hugo) CDH11
LocusID (NCBI) 1009
Atlas_Id 527
Location 16q21  [Link to chromosome band 16q21]
Location_base_pair Starts at 64943753 and ends at 65122137 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDH11 (16q21) / MYO15B (17q25.1)CDH11 (16q21) / USP6 (17p13.2)USP6 (17p13.2) / CDH11 (16q21)
ZFAND2A (7p22.3) / CDH11 (16q21)CDH11 16q21 / USP6 17p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Bone: Aneurysmal bone cysts
Bone: Aneurysmal bone cyst with t(16;17)(q22;p13) CDH11/USP6

External links

Nomenclature
HGNC (Hugo)CDH11   1750
Cards
Entrez_Gene (NCBI)CDH11  1009  cadherin 11
AliasesCAD11; CDHOB; ESWS; OB; 
OSF-4
GeneCards (Weizmann)CDH11
Ensembl hg19 (Hinxton)ENSG00000140937 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140937 [Gene_View]  ENSG00000140937 [Sequence]  chr16:64943753-65122137 [Contig_View]  CDH11 [Vega]
ICGC DataPortalENSG00000140937
TCGA cBioPortalCDH11
AceView (NCBI)CDH11
Genatlas (Paris)CDH11
WikiGenes1009
SOURCE (Princeton)CDH11
Genetics Home Reference (NIH)CDH11
Genomic and cartography
GoldenPath hg38 (UCSC)CDH11  -     chr16:64943753-65122137 -  16q21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDH11  -     16q21   [Description]    (hg19-Feb_2009)
GoldenPathCDH11 - 16q21 [CytoView hg19]  CDH11 - 16q21 [CytoView hg38]
ImmunoBaseENSG00000140937
Mapping of homologs : NCBICDH11 [Mapview hg19]  CDH11 [Mapview hg38]
OMIM211380   600023   
Gene and transcription
Genbank (Entrez)AB209760 AK291251 AK294872 AK297377 AK308000
RefSeq transcript (Entrez)NM_001308392 NM_001330576 NM_001797
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDH11
Cluster EST : UnigeneHs.596112 [ NCBI ]
CGAP (NCI)Hs.596112
Alternative Splicing GalleryENSG00000140937
Gene ExpressionCDH11 [ NCBI-GEO ]   CDH11 [ EBI - ARRAY_EXPRESS ]   CDH11 [ SEEK ]   CDH11 [ MEM ]
Gene Expression Viewer (FireBrowse)CDH11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1009
GTEX Portal (Tissue expression)CDH11
Human Protein AtlasENSG00000140937-CDH11 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55287   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP55287  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP55287
Splice isoforms : SwissVarP55287
PhosPhoSitePlusP55287
Domaine pattern : Prosite (Expaxy)CADHERIN_1 (PS00232)    CADHERIN_2 (PS50268)   
Domains : Interpro (EBI)Cadherin    Cadherin-like    Cadherin_CS    Cadherin_cytoplasmic-dom    Catenin_binding_dom_sf   
Domain families : Pfam (Sanger)Cadherin (PF00028)    Cadherin_C (PF01049)   
Domain families : Pfam (NCBI)pfam00028    pfam01049   
Domain families : Smart (EMBL)CA (SM00112)  
Conserved Domain (NCBI)CDH11
DMDM Disease mutations1009
Blocks (Seattle)CDH11
SuperfamilyP55287
Human Protein Atlas [tissue]ENSG00000140937-CDH11 [tissue]
Peptide AtlasP55287
HPRD08960
IPIIPI00304227   IPI00293539   IPI00909283   IPI00922524   
Protein Interaction databases
DIP (DOE-UCLA)P55287
IntAct (EBI)P55287
FunCoupENSG00000140937
BioGRIDCDH11
STRING (EMBL)CDH11
ZODIACCDH11
Ontologies - Pathways
QuickGOP55287
Ontology : AmiGOcell morphogenesis  skeletal system development  ossification  calcium ion binding  cytoplasm  plasma membrane  plasma membrane  cell-cell adherens junction  cell-cell junction assembly  cell adhesion  homophilic cell adhesion via plasma membrane adhesion molecules  cytoskeletal protein binding  cell surface  integral component of membrane  calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  catenin complex  corticospinal tract morphogenesis  adherens junction organization  adherens junction organization  protein homodimerization activity  cell-cell adhesion mediated by cadherin  cadherin binding  modulation of chemical synaptic transmission  extracellular exosome  cell-cell adhesion  Schaffer collateral - CA1 synapse  glutamatergic synapse  
Ontology : EGO-EBIcell morphogenesis  skeletal system development  ossification  calcium ion binding  cytoplasm  plasma membrane  plasma membrane  cell-cell adherens junction  cell-cell junction assembly  cell adhesion  homophilic cell adhesion via plasma membrane adhesion molecules  cytoskeletal protein binding  cell surface  integral component of membrane  calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  catenin complex  corticospinal tract morphogenesis  adherens junction organization  adherens junction organization  protein homodimerization activity  cell-cell adhesion mediated by cadherin  cadherin binding  modulation of chemical synaptic transmission  extracellular exosome  cell-cell adhesion  Schaffer collateral - CA1 synapse  glutamatergic synapse  
NDEx NetworkCDH11
Atlas of Cancer Signalling NetworkCDH11
Wikipedia pathwaysCDH11
Orthology - Evolution
OrthoDB1009
GeneTree (enSembl)ENSG00000140937
Phylogenetic Trees/Animal Genes : TreeFamCDH11
HOGENOMP55287
Homologs : HomoloGeneCDH11
Homology/Alignments : Family Browser (UCSC)CDH11
Gene fusions - Rearrangements
Fusion : MitelmanCDH11/USP6 [16q21/17p13.2]  
Fusion : QuiverCDH11
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDH11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDH11
dbVarCDH11
ClinVarCDH11
1000_GenomesCDH11 
Exome Variant ServerCDH11
ExAC (Exome Aggregation Consortium)ENSG00000140937
GNOMAD BrowserENSG00000140937
Varsome BrowserCDH11
Genetic variants : HAPMAP1009
Genomic Variants (DGV)CDH11 [DGVbeta]
DECIPHERCDH11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDH11 
Mutations
ICGC Data PortalCDH11 
TCGA Data PortalCDH11 
Broad Tumor PortalCDH11
OASIS PortalCDH11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDH11  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCDH11
Mutations and Diseases : HGMDCDH11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDH11
DgiDB (Drug Gene Interaction Database)CDH11
DoCM (Curated mutations)CDH11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDH11 (select a term)
intoGenCDH11
Cancer3DCDH11(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM211380    600023   
Orphanet
DisGeNETCDH11
MedgenCDH11
Genetic Testing Registry CDH11
NextProtP55287 [Medical]
TSGene1009
GENETestsCDH11
Target ValidationCDH11
Huge Navigator CDH11 [HugePedia]
snp3D : Map Gene to Disease1009
BioCentury BCIQCDH11
ClinGenCDH11
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1009
Chemical/Pharm GKB GenePA26284
Clinical trialCDH11
Miscellaneous
canSAR (ICR)CDH11 (select the gene name)
DataMed IndexCDH11
Probes
Litterature
PubMed76 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDH11
EVEXCDH11
GoPubMedCDH11
iHOPCDH11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:36:28 CET 2019
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