CDH5 (cadherin 5)

2012-04-01  

Identity

HGNC
LOCATION
16q21
LOCUSID
ALIAS
7B4,CD144
FUSION GENES

Other Information

Locus ID:

NCBI: 1003
MIM: 601120
HGNC: 1764
Ensembl: ENSG00000179776

Variants:

dbSNP: 1003
ClinVar: 1003
TCGA: ENSG00000179776
COSMIC: CDH5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179776ENST00000341529P33151
ENSG00000179776ENST00000539168B4DTR2
ENSG00000179776ENST00000562048H3BPG1
ENSG00000179776ENST00000563425I3L1J2
ENSG00000179776ENST00000565334H3BR11
ENSG00000179776ENST00000568023H3BQ82
ENSG00000179776ENST00000568155H3BR64
ENSG00000179776ENST00000614547P33151
ENSG00000179776ENST00000649567P33151

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Leukocyte transendothelial migrationKEGGko04670
Cell adhesion molecules (CAMs)KEGGhsa04514
Leukocyte transendothelial migrationKEGGhsa04670
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
VEGFR2 mediated vascular permeabilityREACTOMER-HSA-5218920
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Adherens junctions interactionsREACTOMER-HSA-418990
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
168939702006Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments.216
156018372005Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway.169
223910382012Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling.162
160271532005Tyrosine phosphorylation of VE-cadherin prevents binding of p120- and beta-catenin and maintains the cellular mesenchymal state.141
161156302005Epac1 regulates integrity of endothelial cell junctions through VE-cadherin.129
229753272012The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2.106
244873202014Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin.104
114900212001Real-time imaging of vascular endothelial-cadherin during leukocyte transmigration across endothelium.97
181950902008Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin.90
184209432008ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin.88

Citation

Dessen P

CDH5 (cadherin 5)

Atlas Genet Cytogenet Oncol Haematol. 2012-04-01

Online version: http://atlasgeneticsoncology.org/gene/52671/cdh5