CDHR5 (cadherin related family member 5)

2011-10-01  

Identity

HGNC
CDHR5
LOCATION
11p15.5
LOCUSID
53841
ALIAS
MLPCDH,MU-PCDH,MUCDHL,MUPCDH
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 53841
MIM: 606839
HGNC: 7521
Ensembl: ENSG00000099834

Variants:

dbSNP: 53841
ClinVar: 53841
TCGA: ENSG00000099834
COSMIC: CDHR5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099834ENST00000397542Q9HBB8
ENSG00000099834ENST00000526077E9PLX6
ENSG00000099834ENST00000531088E9PKR2
ENSG00000099834ENST00000531177E9PMY2
ENSG00000099834ENST00000534311E9PPW2
ENSG00000099834ENST00000674088Q9HBB8

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
247254092014Intestinal brush border assembly driven by protocadherin-based intermicrovillar adhesion.50
222024562012Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and β-catenin activity in colon cancer cells.18
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
121675962002Identification and expression analysis of the human mu-protocadherin gene in fetal and adult kidneys.8
213154192011Down-regulation of μ-protocadherin expression is a common event in colorectal carcinogenesis.5
125894282003Biallelic expression of HRAS and MUCDHL in human and mouse.4
218390662011Polymorphism at the mucin-like protocadherin gene influences susceptibility to gallstone disease.4
264634592015Epigenetic silencing of the MUPCDH gene as a possible prognostic biomarker for cyst growth in ADPKD.2
273108722016Expression of μ-protocadherin is negatively regulated by the activation of the β-catenin signaling pathway in normal and cancer colorectal enterocytes.2

Citation

Dessen P

CDHR5 (cadherin related family member 5)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52395/cdhr5