Identity
HGNC
LOCATION
10q21.2
LOCUSID
ALIAS
CDC2,CDC28A,P34CDC2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 983
MIM: 116940
HGNC: 1722
Ensembl: ENSG00000170312
Variants:
dbSNP: 983
ClinVar: 983
TCGA: ENSG00000170312
COSMIC: CDK1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166122986 | radiotherapy | Chemical | ClinicalAnnotation | associated | PD | 25054431 | |
| PA166124223 | pneumonitis | Disease | ClinicalAnnotation | associated | PD | 25054431 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38103005 | 2024 | Targeting Cyclin-Dependent Kinase 1 Induces Apoptosis and Cell Cycle Arrest of Activated Hepatic Stellate Cells. | 0 |
| 38429268 | 2024 | OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway. | 1 |
| 38640322 | 2024 | CDK1 and CCNA2 play important roles in oral squamous cell carcinoma. | 0 |
| 38103005 | 2024 | Targeting Cyclin-Dependent Kinase 1 Induces Apoptosis and Cell Cycle Arrest of Activated Hepatic Stellate Cells. | 0 |
| 38429268 | 2024 | OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway. | 1 |
| 38640322 | 2024 | CDK1 and CCNA2 play important roles in oral squamous cell carcinoma. | 0 |
| 35348268 | 2023 | NCAPD2 promotes breast cancer progression through E2F1 transcriptional regulation of CDK1. | 8 |
| 36572570 | 2023 | ASRGL1 downregulation suppresses hepatocellular carcinoma tumorigenesis in a CDK1-dependent manner. | 0 |
| 36681899 | 2023 | CDK1 bridges NF-κB and β-catenin signaling in response to H. pylori infection in gastric tumorigenesis. | 7 |
| 36782089 | 2023 | Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions. | 8 |
| 36988891 | 2023 | ELF3 promotes gemcitabine resistance through PKMYT1/CDK1 signaling pathway in gallbladder cancer. | 2 |
| 37216999 | 2023 | BRK confers tamoxifen-resistance in breast cancer via regulation of tyrosine phosphorylation of CDK1. | 0 |
| 37365681 | 2023 | Dynamic phosphorylation of CENP-N by CDK1 guides accurate chromosome segregation in mitosis. | 1 |
| 37428466 | 2023 | Inhibition of CDK1 Overcomes Oxaliplatin Resistance by Regulating ACSL4-mediated Ferroptosis in Colorectal Cancer. | 16 |
| 37667382 | 2023 | Deubiquitylase YOD1 regulates CDK1 stability and drives triple-negative breast cancer tumorigenesis. | 5 |
Citation
Dessen P
CDK1 (cyclin dependent kinase 1)
Atlas Genet Cytogenet Oncol Haematol. 2010-01-01
Online version: http://atlasgeneticsoncology.org/gene/51245/cdk1
