CDK14 (cyclin dependent kinase 14)

2006-10-01  

Identity

HGNC
CDK14
LOCATION
7q21.13
LOCUSID
5218
ALIAS
PFTAIRE1,PFTK1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5218
MIM: 610679
HGNC: 8883
Ensembl: ENSG00000058091

Variants:

dbSNP: 5218
ClinVar: 5218
TCGA: ENSG00000058091
COSMIC: CDK14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000058091ENST00000265741O94921
ENSG00000058091ENST00000380050O94921
ENSG00000058091ENST00000406263O94921
ENSG00000058091ENST00000430760C9IYJ9
ENSG00000058091ENST00000431029F8WF96
ENSG00000058091ENST00000436577E7EUK8
ENSG00000058091ENST00000446224C9IYJ9
ENSG00000058091ENST00000446790C9JWL6
ENSG00000058091ENST00000449528C9IYJ9
ENSG00000058091ENST00000456689C9IYJ9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
290229092017miR-216a inhibits osteosarcoma cell proliferation, invasion and metastasis by targeting CDK14.35
175176222007Functional characterization of human PFTK1 as a cyclin-dependent kinase.20
190587892009A common variant in DRD3 receptor is associated with autism spectrum disorder.19
215772062011A novel interplay between oncogenic PFTK1 protein kinase and tumor suppressor TAGLN2 in the control of liver cancer cell motility.18
296307312018Long non-coding RNA SNHG15 promotes CDK14 expression via miR-486 to accelerate non-small cell lung cancer cells progression and metastasis.18
264884712015PFTK1 Promotes Gastric Cancer Progression by Regulating Proliferation, Migration and Invasion.12
283005912017miR-455 inhibits breast cancer cell proliferation through targeting CDK14.12
304742702019LncRNA H19/miR-194/PFTK1 axis modulates the cell proliferation and migration of pancreatic cancer.10
223335952012Overexpression of PFTK1 predicts resistance to chemotherapy in patients with oesophageal squamous cell carcinoma.9

Citation

Dessen P

CDK14 (cyclin dependent kinase 14)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43407/cdk14