CDK19 (cyclin dependent kinase 19)

2010-01-01  

Identity

HGNC
CDK19
LOCATION
6q21
LOCUSID
23097
ALIAS
CDC2L6,CDK11,DEE87,EIEE87,bA346C16.3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23097
MIM: 614720
HGNC: 19338
Ensembl: ENSG00000155111

Variants:

dbSNP: 23097
ClinVar: 23097
TCGA: ENSG00000155111
COSMIC: CDK19

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155111ENST00000323817Q9BWU1
ENSG00000155111ENST00000368911Q9BWU1
ENSG00000155111ENST00000413605F6QTA4
ENSG00000155111ENST00000457688Q5JQZ9
ENSG00000155111ENST00000463016H0YDW9

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
264167492015Mediator kinase inhibition further activates super-enhancer-associated genes in AML.103
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
237499982013Mediator complex recruits epigenetic regulators via its two cyclin-dependent kinase subunits to repress transcription of immune response genes.30
221178962011Identification of target genes for the CDK subunits of the Mediator complex.19
288553402017CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.16
276784552017Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer.15
284166372017A Kinase-Independent Role for Cyclin-Dependent Kinase 19 in p53 Response.13
305851072019Regulatory functions of the Mediator kinases CDK8 and CDK19.12
294403962018Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.8
260029602015Mediator complex cooperatively regulates transcription of retinoic acid target genes with Polycomb Repressive Complex 2 during neuronal differentiation.5

Citation

Dessen P

CDK19 (cyclin dependent kinase 19)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51315/cdk19