CDK2AP1 (cyclin dependent kinase 2 associated protein 1)

2003-02-01  

Identity

HGNC
CDK2AP1
LOCATION
12q24.31
LOCUSID
8099
ALIAS
DOC1,DORC1,ST19,doc-1,p12DOC-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8099
MIM: 602198
HGNC: 14002
Ensembl: ENSG00000111328

Variants:

dbSNP: 8099
ClinVar: 8099
TCGA: ENSG00000111328
COSMIC: CDK2AP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111328ENST00000261692O14519
ENSG00000111328ENST00000535796F5GZF0
ENSG00000111328ENST00000535979O14519
ENSG00000111328ENST00000538446O14519
ENSG00000111328ENST00000542174O14519
ENSG00000111328ENST00000544658O14519
ENSG00000111328ENST00000618072O14519
ENSG00000111328ENST00000652466O14519

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
196795652009The DNA methylome of pediatric acute lymphoblastic leukemia.32
205553552010IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci.28
213284602011miR-21 downregulates the tumor suppressor P12 CDK2AP1 and stimulates cell proliferation and invasion.22
205239382010CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex.18
147447612004Role of p12(CDK2-AP1) in transforming growth factor-beta1-mediated growth suppression.16
172176202006Loss of p12CDK2-AP1 expression in human oral squamous cell carcinoma with disrupted transforming growth factor-beta-Smad signaling pathway.14
286833242017DOC1-Dependent Recruitment of NURD Reveals Antagonism with SWI/SNF during Epithelial-Mesenchymal Transition in Oral Cancer Cells.14
136798702003Differential expression of DOC-1 in microsatellite-unstable human colorectal cancer.10
195854902009Cell cycle regulator cdk2ap1 inhibits prostate cancer cell growth and modifies androgen-responsive pathway function.8
207274962010Gene expression of oncogenes, antimicrobial peptides, and cytokines in the development of oral leukoplakia.8

Citation

Dessen P

CDK2AP1 (cyclin dependent kinase 2 associated protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40032/cdk2ap1