CDK3 (cyclin dependent kinase 3)

2006-10-01  

Identity

HGNC
LOCATION
17q25.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 1018
MIM: 123828
HGNC: 1772
Ensembl: ENSG00000250506

Variants:

dbSNP: 1018
ClinVar: 1018
TCGA: ENSG00000250506
COSMIC: CDK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000250506ENST00000425876Q00526
ENSG00000250506ENST00000448471Q00526
ENSG00000250506ENST00000586261K7EJ83
ENSG00000250506ENST00000588812K7ELV5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
150842612004Cyclin C/cdk3 promotes Rb-dependent G0 exit.81
255313312015MiR-873 regulates ERα transcriptional activity and tamoxifen resistance via targeting CDK3 in breast cancer cells.27
187941542008Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation.18
264981442016miR-214/199a/199a* cluster levels predict poor survival in hepatocellular carcinoma through interference with cell-cycle regulators.12
289395912018miR-125a-3p inhibits ERα transactivation and overrides tamoxifen resistance by targeting CDK3 in estrogen receptor-positive breast cancer.12
293448502018HuR facilitates cancer stemness of lung cancer cells via regulating miR-873/CDK3 and miR-125a-3p/CDK3 axis.10
285010052017HuR promotes breast cancer cell proliferation and survival via binding to CDK3 mRNA.9
210677902011The retroviral cyclin of walleye dermal sarcoma virus binds cyclin-dependent kinases 3 and 8.6
267556512016Cdk3-promoted epithelial-mesenchymal transition through activating AP-1 is involved in colorectal cancer metastasis.4
246915372014CDK3 expression and its clinical significance in human nasopharyngeal carcinoma.3

Citation

Dessen P

CDK3 (cyclin dependent kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43201/cdk3