Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CDK8 (cyclin dependent kinase 8)

Identity

Alias (NCBI)IDDHBA
K35
HGNC (Hugo) CDK8
HGNC Alias symbK35
HGNC Previous namecyclin-dependent kinase 8
LocusID (NCBI) 1024
Atlas_Id 40036
Location 13q12.13  [Link to chromosome band 13q12]
Location_base_pair Starts at 26254129 and ends at 26405236 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDK8 (13q12.13) / IKZF3 (17q12)PACS1 (11q13.1) / CDK8 (13q12.13)RPL7L1 (6p21.1) / CDK8 (13q12.13)
CDK8 13q12.13 / IKZF3 17q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(3;5)(q26;q31) H2AFY/MECOM

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  Lung: Translocations in Squamous Cell Carcinoma
t(6;13)(p21;q12) RPL7L1/CDK8
t(13;17)(q12;q12) CDK8/IKZF3

External links

Nomenclature
HGNC (Hugo)CDK8   1779
Cards
Entrez_Gene (NCBI)CDK8    cyclin dependent kinase 8
AliasesIDDHBA; K35
GeneCards (Weizmann)CDK8
Ensembl hg19 (Hinxton)ENSG00000132964 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132964 [Gene_View]  ENSG00000132964 [Sequence]  chr13:26254129-26405236 [Contig_View]  CDK8 [Vega]
ICGC DataPortalENSG00000132964
TCGA cBioPortalCDK8
AceView (NCBI)CDK8
Genatlas (Paris)CDK8
SOURCE (Princeton)CDK8
Genetics Home Reference (NIH)CDK8
Genomic and cartography
GoldenPath hg38 (UCSC)CDK8  -     chr13:26254129-26405236 +  13q12.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDK8  -     13q12.13   [Description]    (hg19-Feb_2009)
GoldenPathCDK8 - 13q12.13 [CytoView hg19]  CDK8 - 13q12.13 [CytoView hg38]
ImmunoBaseENSG00000132964
genome Data Viewer NCBICDK8 [Mapview hg19]  
OMIM603184   618748   
Gene and transcription
Genbank (Entrez)AK296084 AK296875 AY702976 BC069634 BC094784
RefSeq transcript (Entrez)NM_001260 NM_001318368 NM_001346501
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDK8
Alternative Splicing GalleryENSG00000132964
Gene ExpressionCDK8 [ NCBI-GEO ]   CDK8 [ EBI - ARRAY_EXPRESS ]   CDK8 [ SEEK ]   CDK8 [ MEM ]
Gene Expression Viewer (FireBrowse)CDK8 [ Firebrowse - Broad ]
GenevisibleExpression of CDK8 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1024
GTEX Portal (Tissue expression)CDK8
Human Protein AtlasENSG00000132964-CDK8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49336   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49336  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49336
Splice isoforms : SwissVarP49336
Catalytic activity : Enzyme2.7.11.22 [ Enzyme-Expasy ]   2.7.11.222.7.11.22 [ IntEnz-EBI ]   2.7.11.22 [ BRENDA ]   2.7.11.22 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP49336
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CDK8
Blocks (Seattle)CDK8
PDB (RSDB)3RGF    4CRL    4F6S    4F6U    4F6W    4F70    4F7J    4F7L    4F7N    4F7S    4G6L    5BNJ    5CEI    5FGK    5HBE    5HBH    5HBJ    5HNB    5HVY    5I5Z    5ICP    5IDN    5IDP    5XQX    5XS2    6T41   
PDB Europe3RGF    4CRL    4F6S    4F6U    4F6W    4F70    4F7J    4F7L    4F7N    4F7S    4G6L    5BNJ    5CEI    5FGK    5HBE    5HBH    5HBJ    5HNB    5HVY    5I5Z    5ICP    5IDN    5IDP    5XQX    5XS2    6T41   
PDB (PDBSum)3RGF    4CRL    4F6S    4F6U    4F6W    4F70    4F7J    4F7L    4F7N    4F7S    4G6L    5BNJ    5CEI    5FGK    5HBE    5HBH    5HBJ    5HNB    5HVY    5I5Z    5ICP    5IDN    5IDP    5XQX    5XS2    6T41   
PDB (IMB)3RGF    4CRL    4F6S    4F6U    4F6W    4F70    4F7J    4F7L    4F7N    4F7S    4G6L    5BNJ    5CEI    5FGK    5HBE    5HBH    5HBJ    5HNB    5HVY    5I5Z    5ICP    5IDN    5IDP    5XQX    5XS2    6T41   
Structural Biology KnowledgeBase3RGF    4CRL    4F6S    4F6U    4F6W    4F70    4F7J    4F7L    4F7N    4F7S    4G6L    5BNJ    5CEI    5FGK    5HBE    5HBH    5HBJ    5HNB    5HVY    5I5Z    5ICP    5IDN    5IDP    5XQX    5XS2    6T41   
SCOP (Structural Classification of Proteins)3RGF    4CRL    4F6S    4F6U    4F6W    4F70    4F7J    4F7L    4F7N    4F7S    4G6L    5BNJ    5CEI    5FGK    5HBE    5HBH    5HBJ    5HNB    5HVY    5I5Z    5ICP    5IDN    5IDP    5XQX    5XS2    6T41   
CATH (Classification of proteins structures)3RGF    4CRL    4F6S    4F6U    4F6W    4F70    4F7J    4F7L    4F7N    4F7S    4G6L    5BNJ    5CEI    5FGK    5HBE    5HBH    5HBJ    5HNB    5HVY    5I5Z    5ICP    5IDN    5IDP    5XQX    5XS2    6T41   
SuperfamilyP49336
Human Protein Atlas [tissue]ENSG00000132964-CDK8 [tissue]
Peptide AtlasP49336
HPRD04422
IPIIPI00026791   IPI00879595   IPI00470693   
Protein Interaction databases
DIP (DOE-UCLA)P49336
IntAct (EBI)P49336
BioGRIDCDK8
STRING (EMBL)CDK8
ZODIACCDK8
Ontologies - Pathways
QuickGOP49336
Ontology : AmiGOprotein kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleolus  transcription initiation from RNA polymerase II promoter  protein phosphorylation  RNA polymerase II CTD heptapeptide repeat kinase activity  mediator complex  mediator complex  protein-containing complex  positive regulation of transcription by RNA polymerase II  regulation of cell cycle  
Ontology : EGO-EBIprotein kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleolus  transcription initiation from RNA polymerase II promoter  protein phosphorylation  RNA polymerase II CTD heptapeptide repeat kinase activity  mediator complex  mediator complex  protein-containing complex  positive regulation of transcription by RNA polymerase II  regulation of cell cycle  
NDEx NetworkCDK8
Atlas of Cancer Signalling NetworkCDK8
Wikipedia pathwaysCDK8
Orthology - Evolution
OrthoDB1024
GeneTree (enSembl)ENSG00000132964
Phylogenetic Trees/Animal Genes : TreeFamCDK8
HOGENOMP49336
Homologs : HomoloGeneCDK8
Homology/Alignments : Family Browser (UCSC)CDK8
Gene fusions - Rearrangements
Fusion : MitelmanCDK8/IKZF3 [13q12.13/17q12]  
Fusion : MitelmanRPL7L1/CDK8 [6p21.1/13q12.13]  
Fusion PortalCDK8 13q12.13 IKZF3 17q12 BRCA
Fusion : QuiverCDK8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDK8 [hg38]
dbVarCDK8
ClinVarCDK8
MonarchCDK8
1000_GenomesCDK8 
Exome Variant ServerCDK8
GNOMAD BrowserENSG00000132964
Varsome BrowserCDK8
Genomic Variants (DGV)CDK8 [DGVbeta]
DECIPHERCDK8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDK8 
Mutations
ICGC Data PortalCDK8 
TCGA Data PortalCDK8 
Broad Tumor PortalCDK8
OASIS PortalCDK8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDK8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCDK8
Mutations and Diseases : HGMDCDK8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDK8
DgiDB (Drug Gene Interaction Database)CDK8
DoCM (Curated mutations)CDK8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDK8 (select a term)
intoGenCDK8
Cancer3DCDK8(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603184    618748   
Orphanet
DisGeNETCDK8
MedgenCDK8
Genetic Testing Registry CDK8
NextProtP49336 [Medical]
GENETestsCDK8
Target ValidationCDK8
Huge Navigator CDK8 [HugePedia]
ClinGenCDK8
Clinical trials, drugs, therapy
MyCancerGenomeCDK8
Protein Interactions : CTD
Pharm GKB GenePA26315
PharosP49336
Clinical trialCDK8
Miscellaneous
canSAR (ICR)CDK8 (select the gene name)
HarmonizomeCDK8
DataMed IndexCDK8
Probes
Litterature
PubMed130 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCDK8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:09:26 CET 2021
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