CDKN2AIP (CDKN2A interacting protein)

2008-07-01  

Identity

HGNC
LOCATION
4q35.1
LOCUSID
ALIAS
CARF

Other Information

Locus ID:

NCBI: 55602
MIM: 615914
HGNC: 24325
Ensembl: ENSG00000168564

Variants:

dbSNP: 55602
ClinVar: 55602
TCGA: ENSG00000168564
COSMIC: CDKN2AIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168564ENST00000302350J3KNE1
ENSG00000168564ENST00000504169Q9NXV6
ENSG00000168564ENST00000510928D6RGD2

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
121540872002CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53.18
190013762009CARF Is a vital dual regulator of cellular senescence and apoptosis.14
210520952011Molecular characterization of apoptosis induced by CARF silencing in human cancer cells.12
182929442008CARF (collaborator of ARF) interacts with HDM2: evidence for a novel regulatory feedback regulation of CARF-p53-HDM2-p21WAF1 pathway.10
248259082014Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling.10
262789982015CARF (Collaborator of ARF) overexpression in p53-deficient cells promotes carcinogenesis.9
174601932007CARF binds to three members (ARF, p53, and HDM2) of the p53 tumor-suppressor pathway.6
265318222015Collaborator of alternative reading frame protein (CARF) regulates early processing of pre-ribosomal RNA by retaining XRN2 (5'-3' exoribonuclease) in the nucleoplasm.6
185555162009CARF: an emerging regulator of p53 tumor suppressor and senescence pathway.4
274571282016Loss-of-function screening to identify miRNAs involved in senescence: tumor suppressor activity of miRNA-335 and its new target CARF.4

Citation

Dessen P

CDKN2AIP (CDKN2A interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50210/cdkn2aip