CDO1 (cysteine dioxygenase type 1)

2010-08-01  

Identity

HGNC
LOCATION
5q22.3
LOCUSID
ALIAS
CDO-I

Other Information

Locus ID:

NCBI: 1036
MIM: 603943
HGNC: 1795
Ensembl: ENSG00000129596

Variants:

dbSNP: 1036
ClinVar: 1036
TCGA: ENSG00000129596
COSMIC: CDO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129596ENST00000250535Q16878

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Taurine and hypotaurine metabolismKEGGko00430
Taurine and hypotaurine metabolismKEGGhsa00430
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Sulfur amino acid metabolismREACTOMER-HSA-1614635
Degradation of cysteine and homocysteineREACTOMER-HSA-1614558

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
220116692012Genome-wide analysis of DNA methylation and the gene expression change in lung cancer.43
230286992012Cysteine dioxygenase 1 is a tumor suppressor gene silenced by promoter methylation in multiple human cancers.42
180333142008Sézary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3.30
173273712007Overexpression of cysteine dioxygenase reduces intracellular cysteine and glutathione pools in HepG2/C3A cells.29
249480442015The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are frequently methylated across gastrointestinal cancers.26
244865892014Functional identification of cancer-specific methylation of CDO1, HOXA9, and TAC1 for the diagnosis of lung cancer.25
205154692010CDO1 promoter methylation is a biomarker for outcome prediction of anthracycline treated, estrogen receptor-positive, lymph node-positive breast cancer patients.23
276894752016CDO1 promoter methylation is associated with gene silencing and is a prognostic biomarker for biochemical recurrence-free survival in prostate cancer patients.20
259047532015Promoter Methylation of CDO1 Identifies Clear-Cell Renal Cell Cancer Patients with Poor Survival Outcome.17
267853252016Prognostic Significance of Promoter DNA Hypermethylation of cysteine dioxygenase 1 (CDO1) Gene in Primary Breast Cancer.17

Citation

Dessen P

CDO1 (cysteine dioxygenase type 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51629/cdo1