CDON (cell adhesion associated, oncogene regulated)

2003-06-01  

Identity

HGNC
CDON
LOCATION
11q24.2
LOCUSID
50937
ALIAS
CDO,CDON1,HPE11,Ihog,ORCAM
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 50937
MIM: 608707
HGNC: 17104
Ensembl: ENSG00000064309

Variants:

dbSNP: 50937
ClinVar: 50937
TCGA: ENSG00000064309
COSMIC: CDON

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000064309ENST00000263577Q4KMG0
ENSG00000064309ENST00000392693Q4KMG0
ENSG00000064309ENST00000527967E9PPQ7
ENSG00000064309ENST00000531586E9PRD8
ENSG00000064309ENST00000531738E9PN78
ENSG00000064309ENST00000531830H0YCZ4
ENSG00000064309ENST00000534661H0YEX4
ENSG00000064309ENST00000534818E9PNF2

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Hedgehog signaling pathwayKEGGko04340
Hedgehog signaling pathwayKEGGhsa04340
Signal TransductionREACTOMER-HSA-162582
Signaling by HedgehogREACTOMER-HSA-5358351
Hedgehog 'on' stateREACTOMER-HSA-5632684
Ligand-receptor interactionsREACTOMER-HSA-5632681
Activation of SMOREACTOMER-HSA-5635838
Developmental BiologyREACTOMER-HSA-1266738
MyogenesisREACTOMER-HSA-525793
CDO in myogenesisREACTOMER-HSA-375170

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
218020632011Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors.50
126201902003Microform holoprosencephaly in mice that lack the Ig superfamily member Cdon.43
126344282003Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation.37
205194952010All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.25
247408422014Genetic variants in microRNAs and microRNA target sites predict biochemical recurrence after radical prostatectomy in localized prostate cancer.24
223266212012Cdon and Boc: Two transmembrane proteins implicated in cell-cell communication.9
127202942003Overexpression of the immunoglobulin superfamily members CDO and BOC enhances differentiation of the human rhabdomyosarcoma cell line RD.8
253132462014Regulation by miR181 family of the dependence receptor CDON tumor suppressive activity in neuroblastoma.8
265296312016A Nonsense Mutation in the Hedgehog Receptor CDON Associated With Pituitary Stalk Interruption Syndrome.8

Citation

Dessen P

CDON (cell adhesion associated, oncogene regulated)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40040/cdon