CELA3B (chymotrypsin like elastase 3B)

2010-10-01  

Identity

HGNC
CELA3B
LOCATION
1p36.12
LOCUSID
23436
ALIAS
CBPP,ELA3B

Other Information

Locus ID:

NCBI: 23436
MIM: 618694
HGNC: 15945
Ensembl: ENSG00000219073

Variants:

dbSNP: 23436
ClinVar: 23436
TCGA: ENSG00000219073
COSMIC: CELA3B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000219073ENST00000337107P08861
ENSG00000219073ENST00000400277A0A0A0MSA6

Expression (GTEx)

0
5000
10000
15000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
220949302011Partial pancreatic resection for pancreatic malignancy is associated with sustained pancreatic exocrine failure and reduced quality of life: a prospective study.16
227496482012Faecal elastase-1 is an independent predictor of survival in advanced pancreatic cancer.16
153517202004Proinflammatory effects of pancreatic elastase are mediated through TLR4 and NF-kappaB.14
152774402004Pancreatic elastase-1 in stools, a marker of exocrine pancreas function, correlates with both residual beta-cell secretion and metabolic control in type 1 diabetic subjects.12
171034882007Pancreatin therapy in patients with insulin-treated diabetes mellitus and exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations. Results of a prospective multi-centre trial.11
246847712014Human type I pancreatic elastase treatment of arteriovenous fistulas in patients with chronic kidney disease.11
183628412008Low fecal elastase 1 levels do not indicate exocrine pancreatic insufficiency in type-1 diabetes mellitus.10
179893092008Pancreatic exocrine dysfunction in maturity-onset diabetes of the young type 3.8
273584032016Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.8
204288262010Identification of pancreatic juice proteins as biomarkers of pancreatic cancer.7

Citation

Dessen P

CELA3B (chymotrypsin like elastase 3B)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51704/cela3b