Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CELSR2 (cadherin EGF LAG seven-pass G-type receptor 2)

Identity

Alias (NCBI)ADGRC2
CDHF10
EGFL2
Flamingo1
MEGF3
HGNC (Hugo) CELSR2
HGNC Alias symbKIAA0279
MEGF3
Flamingo1
CDHF10
ADGRC2
HGNC Alias nameadhesion G protein-coupled receptor C2
HGNC Previous nameEGFL2
HGNC Previous namecadherin, EGF LAG seven-pass G-type receptor 2, flamingo (Drosophila) homolog
 cadherin, EGF LAG seven-pass G-type receptor 2
LocusID (NCBI) 1952
Atlas_Id 57777
Location 1p13.3  [Link to chromosome band 1p13]
Location_base_pair Starts at 109249539 and ends at 109275751 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CELSR2 (1p13.3) / CALM3 (19q13.32)CELSR2 (1p13.3) / SARS (1p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  CELSR2/SARS (1p13)


External links

Nomenclature
HGNC (Hugo)CELSR2   3231
Cards
Entrez_Gene (NCBI)CELSR2  1952  cadherin EGF LAG seven-pass G-type receptor 2
AliasesADGRC2; CDHF10; EGFL2; Flamingo1; 
MEGF3
GeneCards (Weizmann)CELSR2
Ensembl hg19 (Hinxton)ENSG00000143126 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143126 [Gene_View]  ENSG00000143126 [Sequence]  chr1:109249539-109275751 [Contig_View]  CELSR2 [Vega]
ICGC DataPortalENSG00000143126
TCGA cBioPortalCELSR2
AceView (NCBI)CELSR2
Genatlas (Paris)CELSR2
WikiGenes1952
SOURCE (Princeton)CELSR2
Genetics Home Reference (NIH)CELSR2
Genomic and cartography
GoldenPath hg38 (UCSC)CELSR2  -     chr1:109249539-109275751 +  1p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CELSR2  -     1p13.3   [Description]    (hg19-Feb_2009)
GoldenPathCELSR2 - 1p13.3 [CytoView hg19]  CELSR2 - 1p13.3 [CytoView hg38]
ImmunoBaseENSG00000143126
genome Data Viewer NCBICELSR2 [Mapview hg19]  
OMIM604265   
Gene and transcription
Genbank (Entrez)AF234887 AK124727 AK127086 AK127745 AK309093
RefSeq transcript (Entrez)NM_001408
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CELSR2
Alternative Splicing GalleryENSG00000143126
Gene ExpressionCELSR2 [ NCBI-GEO ]   CELSR2 [ EBI - ARRAY_EXPRESS ]   CELSR2 [ SEEK ]   CELSR2 [ MEM ]
Gene Expression Viewer (FireBrowse)CELSR2 [ Firebrowse - Broad ]
GenevisibleExpression of CELSR2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1952
GTEX Portal (Tissue expression)CELSR2
Human Protein AtlasENSG00000143126-CELSR2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HCU4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HCU4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HCU4
Splice isoforms : SwissVarQ9HCU4
PhosPhoSitePlusQ9HCU4
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    CADHERIN_1 (PS00232)    CADHERIN_2 (PS50268)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_LAM_1 (PS01248)    EGF_LAM_2 (PS50027)    G_PROTEIN_RECEP_F2_3 (PS50227)    G_PROTEIN_RECEP_F2_4 (PS50261)    GPS (PS50221)    LAM_G_DOMAIN (PS50025)   
Domains : Interpro (EBI)Cadherin-like_dom    Cadherin-like_sf    Cadherin_CS    ConA-like_dom_sf    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    GAIN_dom_N    GPCR_2-like    GPCR_2_extracell_dom_sf    GPCR_2_extracellular_dom    GPCR_2_secretin-like    GPS    Growth_fac_rcpt_cys_sf    Laminin_EGF    Laminin_G   
Domain families : Pfam (Sanger)7tm_2 (PF00002)    Cadherin (PF00028)    EGF (PF00008)    GAIN (PF16489)    GPS (PF01825)    hEGF (PF12661)    Laminin_EGF (PF00053)    Laminin_G_2 (PF02210)   
Domain families : Pfam (NCBI)pfam00002    pfam00028    pfam00008    pfam16489    pfam01825    pfam12661    pfam00053    pfam02210   
Domain families : Smart (EMBL)CA (SM00112)  EGF (SM00181)  EGF_CA (SM00179)  EGF_Lam (SM00180)  GPS (SM00303)  HormR (SM00008)  LamG (SM00282)  
Conserved Domain (NCBI)CELSR2
DMDM Disease mutations1952
Blocks (Seattle)CELSR2
SuperfamilyQ9HCU4
Human Protein Atlas [tissue]ENSG00000143126-CELSR2 [tissue]
Peptide AtlasQ9HCU4
IPIIPI00015346   IPI00444112   IPI00444821   
Protein Interaction databases
DIP (DOE-UCLA)Q9HCU4
IntAct (EBI)Q9HCU4
FunCoupENSG00000143126
BioGRIDCELSR2
STRING (EMBL)CELSR2
ZODIACCELSR2
Ontologies - Pathways
QuickGOQ9HCU4
Ontology : AmiGOneuron migration  cilium movement  G protein-coupled receptor activity  calcium ion binding  cytoplasm  plasma membrane  regulation of transcription, DNA-templated  homophilic cell adhesion via plasma membrane adhesion molecules  G protein-coupled receptor signaling pathway  integral component of membrane  Wnt signaling pathway  ventricular system development  neural plate anterior/posterior regionalization  regulation of cell-cell adhesion  regulation of protein localization  cerebrospinal fluid secretion  dendrite morphogenesis  Wnt signaling pathway, planar cell polarity pathway  cilium assembly  cell-cell adhesion  
Ontology : EGO-EBIneuron migration  cilium movement  G protein-coupled receptor activity  calcium ion binding  cytoplasm  plasma membrane  regulation of transcription, DNA-templated  homophilic cell adhesion via plasma membrane adhesion molecules  G protein-coupled receptor signaling pathway  integral component of membrane  Wnt signaling pathway  ventricular system development  neural plate anterior/posterior regionalization  regulation of cell-cell adhesion  regulation of protein localization  cerebrospinal fluid secretion  dendrite morphogenesis  Wnt signaling pathway, planar cell polarity pathway  cilium assembly  cell-cell adhesion  
NDEx NetworkCELSR2
Atlas of Cancer Signalling NetworkCELSR2
Wikipedia pathwaysCELSR2
Orthology - Evolution
OrthoDB1952
GeneTree (enSembl)ENSG00000143126
Phylogenetic Trees/Animal Genes : TreeFamCELSR2
HOGENOMQ9HCU4
Homologs : HomoloGeneCELSR2
Homology/Alignments : Family Browser (UCSC)CELSR2
Gene fusions - Rearrangements
Fusion : QuiverCELSR2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCELSR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CELSR2
dbVarCELSR2
ClinVarCELSR2
1000_GenomesCELSR2 
Exome Variant ServerCELSR2
GNOMAD BrowserENSG00000143126
Varsome BrowserCELSR2
Genetic variants : HAPMAP1952
Genomic Variants (DGV)CELSR2 [DGVbeta]
DECIPHERCELSR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCELSR2 
Mutations
ICGC Data PortalCELSR2 
TCGA Data PortalCELSR2 
Broad Tumor PortalCELSR2
OASIS PortalCELSR2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCELSR2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCELSR2
Mutations and Diseases : HGMDCELSR2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CELSR2
DgiDB (Drug Gene Interaction Database)CELSR2
DoCM (Curated mutations)CELSR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CELSR2 (select a term)
intoGenCELSR2
Cancer3DCELSR2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604265   
Orphanet
DisGeNETCELSR2
MedgenCELSR2
Genetic Testing Registry CELSR2
NextProtQ9HCU4 [Medical]
TSGene1952
GENETestsCELSR2
Target ValidationCELSR2
Huge Navigator CELSR2 [HugePedia]
snp3D : Map Gene to Disease1952
BioCentury BCIQCELSR2
ClinGenCELSR2
Clinical trials, drugs, therapy
Protein Interactions : CTD1952
Pharm GKB GenePA26394
Clinical trialCELSR2
Miscellaneous
canSAR (ICR)CELSR2 (select the gene name)
HarmonizomeCELSR2
DataMed IndexCELSR2
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCELSR2
EVEXCELSR2
GoPubMedCELSR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jul 16 15:07:18 CEST 2020

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