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CENPE (centromere protein E)

Identity

Alias (NCBI)CENP-E
KIF10
MCPH13
PPP1R61
HGNC (Hugo) CENPE
HGNC Alias symbKIF10
PPP1R61
HGNC Alias nameprotein phosphatase 1, regulatory subunit 61
HGNC Previous namecentromere protein E (312kD)
 centromere protein E, 312kDa
LocusID (NCBI) 1062
Atlas_Id 40056
Location 4q24  [Link to chromosome band 4q24]
Location_base_pair Starts at 103105811 and ends at 103198343 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FAHD1 (16p13.3) / CENPE (4q24)SPATA5 (4q28.1) / CENPE (4q24)SPATA5 4q28.1 / CENPE 4q24

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)CENPE   1856
Cards
Entrez_Gene (NCBI)CENPE    centromere protein E
AliasesCENP-E; KIF10; MCPH13; PPP1R61
GeneCards (Weizmann)CENPE
Ensembl hg19 (Hinxton)ENSG00000138778 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138778 [Gene_View]  ENSG00000138778 [Sequence]  chr4:103105811-103198343 [Contig_View]  CENPE [Vega]
ICGC DataPortalENSG00000138778
TCGA cBioPortalCENPE
AceView (NCBI)CENPE
Genatlas (Paris)CENPE
SOURCE (Princeton)CENPE
Genetics Home Reference (NIH)CENPE
Genomic and cartography
GoldenPath hg38 (UCSC)CENPE  -     chr4:103105811-103198343 -  4q24   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CENPE  -     4q24   [Description]    (hg19-Feb_2009)
GoldenPathCENPE - 4q24 [CytoView hg19]  CENPE - 4q24 [CytoView hg38]
ImmunoBaseENSG00000138778
genome Data Viewer NCBICENPE [Mapview hg19]  
OMIM117143   616051   
Gene and transcription
Genbank (Entrez)AA210728 AA210858 AB209996 AK290362 AL596934
RefSeq transcript (Entrez)NM_001286734 NM_001813
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CENPE
Alternative Splicing GalleryENSG00000138778
Gene ExpressionCENPE [ NCBI-GEO ]   CENPE [ EBI - ARRAY_EXPRESS ]   CENPE [ SEEK ]   CENPE [ MEM ]
Gene Expression Viewer (FireBrowse)CENPE [ Firebrowse - Broad ]
GenevisibleExpression of CENPE in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1062
GTEX Portal (Tissue expression)CENPE
Human Protein AtlasENSG00000138778-CENPE [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02224   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02224  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02224
Splice isoforms : SwissVarQ02224
PhosPhoSitePlusQ02224
Domaine pattern : Prosite (Expaxy)KINESIN_MOTOR_1 (PS00411)    KINESIN_MOTOR_2 (PS50067)   
Domains : Interpro (EBI)Kinesin_motor_CS    Kinesin_motor_dom    Kinesin_motor_dom_sf    P-loop_NTPase   
Domain families : Pfam (Sanger)Kinesin (PF00225)   
Domain families : Pfam (NCBI)pfam00225   
Domain families : Smart (EMBL)KISc (SM00129)  
Conserved Domain (NCBI)CENPE
Blocks (Seattle)CENPE
PDB (RSDB)1T5C    5JVP   
PDB Europe1T5C    5JVP   
PDB (PDBSum)1T5C    5JVP   
PDB (IMB)1T5C    5JVP   
Structural Biology KnowledgeBase1T5C    5JVP   
SCOP (Structural Classification of Proteins)1T5C    5JVP   
CATH (Classification of proteins structures)1T5C    5JVP   
SuperfamilyQ02224
Human Protein Atlas [tissue]ENSG00000138778-CENPE [tissue]
Peptide AtlasQ02224
HPRD00316
IPIIPI00296365   IPI00868715   IPI00619925   IPI00967647   
Protein Interaction databases
DIP (DOE-UCLA)Q02224
IntAct (EBI)Q02224
BioGRIDCENPE
STRING (EMBL)CENPE
ZODIACCENPE
Ontologies - Pathways
QuickGOQ02224
Ontology : AmiGOmitotic cell cycle  mitotic cell cycle  chromosome, centromeric region  kinetochore  condensed chromosome kinetochore  condensed chromosome, centromeric region  microtubule motor activity  microtubule motor activity  protein binding  ATP binding  nucleus  nucleoplasm  chromosome  kinetochore microtubule  cytosol  cytosol  microtubule  microtubule  retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  microtubule-based movement  microtubule-based movement  mitotic spindle organization  chromosome segregation  mitotic chromosome movement towards spindle pole  mitotic metaphase plate congression  multicellular organism development  microtubule binding  microtubule binding  ATP-dependent microtubule motor activity, plus-end-directed  microtubule cytoskeleton  membrane  antigen processing and presentation of exogenous peptide antigen via MHC class II  regulation of mitotic metaphase/anaphase transition  midbody  kinetochore binding  positive regulation of protein kinase activity  spindle midzone  cell division  metaphase plate congression  attachment of mitotic spindle microtubules to kinetochore  kinetochore assembly  microtubule plus-end directed mitotic chromosome migration  lateral attachment of mitotic spindle microtubules to kinetochore  mitotic spindle midzone  
Ontology : EGO-EBImitotic cell cycle  mitotic cell cycle  chromosome, centromeric region  kinetochore  condensed chromosome kinetochore  condensed chromosome, centromeric region  microtubule motor activity  microtubule motor activity  protein binding  ATP binding  nucleus  nucleoplasm  chromosome  kinetochore microtubule  cytosol  cytosol  microtubule  microtubule  retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  microtubule-based movement  microtubule-based movement  mitotic spindle organization  chromosome segregation  mitotic chromosome movement towards spindle pole  mitotic metaphase plate congression  multicellular organism development  microtubule binding  microtubule binding  ATP-dependent microtubule motor activity, plus-end-directed  microtubule cytoskeleton  membrane  antigen processing and presentation of exogenous peptide antigen via MHC class II  regulation of mitotic metaphase/anaphase transition  midbody  kinetochore binding  positive regulation of protein kinase activity  spindle midzone  cell division  metaphase plate congression  attachment of mitotic spindle microtubules to kinetochore  kinetochore assembly  microtubule plus-end directed mitotic chromosome migration  lateral attachment of mitotic spindle microtubules to kinetochore  mitotic spindle midzone  
NDEx NetworkCENPE
Atlas of Cancer Signalling NetworkCENPE
Wikipedia pathwaysCENPE
Orthology - Evolution
OrthoDB1062
GeneTree (enSembl)ENSG00000138778
Phylogenetic Trees/Animal Genes : TreeFamCENPE
HOGENOMQ02224
Homologs : HomoloGeneCENPE
Homology/Alignments : Family Browser (UCSC)CENPE
Gene fusions - Rearrangements
Fusion : MitelmanSPATA5/CENPE [4q28.1/4q24]  
Fusion PortalSPATA5 4q28.1 CENPE 4q24 BRCA
Fusion : QuiverCENPE
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCENPE [hg38]
dbVarCENPE
ClinVarCENPE
MonarchCENPE
1000_GenomesCENPE 
Exome Variant ServerCENPE
GNOMAD BrowserENSG00000138778
Varsome BrowserCENPE
Genomic Variants (DGV)CENPE [DGVbeta]
DECIPHERCENPE [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCENPE 
Mutations
ICGC Data PortalCENPE 
TCGA Data PortalCENPE 
Broad Tumor PortalCENPE
OASIS PortalCENPE [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCENPE  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCENPE
Mutations and Diseases : HGMDCENPE
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CENPE
DgiDB (Drug Gene Interaction Database)CENPE
DoCM (Curated mutations)CENPE (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CENPE (select a term)
intoGenCENPE
Cancer3DCENPE(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM117143    616051   
Orphanet954   
DisGeNETCENPE
MedgenCENPE
Genetic Testing Registry CENPE
NextProtQ02224 [Medical]
GENETestsCENPE
Target ValidationCENPE
Huge Navigator CENPE [HugePedia]
ClinGenCENPE
Clinical trials, drugs, therapy
MyCancerGenomeCENPE
Protein Interactions : CTD
Pharm GKB GenePA26400
PharosQ02224
Clinical trialCENPE
Miscellaneous
canSAR (ICR)CENPE (select the gene name)
HarmonizomeCENPE
DataMed IndexCENPE
Probes
Litterature
PubMed100 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCENPE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 25 19:15:09 CET 2021

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