CENPE (centromere protein E)

2003-08-01  

Identity

HGNC
CENPE
LOCATION
4q24
LOCUSID
1062
ALIAS
CENP-E,KIF10,MCPH13,PPP1R61
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1062
MIM: 117143
HGNC: 1856
Ensembl: ENSG00000138778

Variants:

dbSNP: 1062
ClinVar: 1062
TCGA: ENSG00000138778
COSMIC: CENPE

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138778ENST00000265148Q02224
ENSG00000138778ENST00000380026Q02224
ENSG00000138778ENST00000514974D6RHK2
ENSG00000138778ENST00000611174A0A087X0P0

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
KinesinsREACTOMER-HSA-983189
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
206919032010Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E.104
183746472008SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis.101
126866152003Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores.73
195259382009Chromosome congression in the absence of kinetochore fibres.73
259086622015Mitosis. Microtubule detyrosination guides chromosomes during mitosis.65
161449042005Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling.62
253836602014Kinetochore motors drive congression of peripheral polar chromosomes by overcoming random arm-ejection forces.48
151811472004Gene silencing of CENP-E by small interfering RNA in HeLa cells leads to missegregation of chromosomes after a mitotic delay.45
197330752009Motor-independent targeting of CLASPs to kinetochores by CENP-E promotes microtubule turnover and poleward flux.42
238911082013Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK.42

Citation

Dessen P

CENPE (centromere protein E)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40056/cenpe