CENPH (centromere protein H)

2007-02-01  

Identity

HGNC
LOCATION
5q13.2
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 64946
MIM: 605607
HGNC: 17268
Ensembl: ENSG00000153044

Variants:

dbSNP: 64946
ClinVar: 64946
TCGA: ENSG00000153044
COSMIC: CENPH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153044ENST00000283006Q9H3R5
ENSG00000153044ENST00000283006A0A0S2Z5T0
ENSG00000153044ENST00000502689H0Y9E6
ENSG00000153044ENST00000513575D6RBJ6
ENSG00000153044ENST00000515001B3KVZ3

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Chromosome MaintenanceREACTOMER-HSA-73886
Nucleosome assemblyREACTOMER-HSA-774815
Deposition of new CENPA-containing nucleosomes at the centromereREACTOMER-HSA-606279

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
166224202006The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.195
180459862008KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates.81
196254492009CENP-H-containing complex facilitates centromere deposition of CENP-A in cooperation with FACT and CHD1.63
159302862005Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidy.44
176514962007Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres.32
191702372009Centromere protein H is a novel prognostic marker for human nonsmall cell lung cancer progression and overall patient survival.27
172552722007Centromere protein H is a novel prognostic marker for nasopharyngeal carcinoma progression and overall patient survival.25
192325192009TRIM36 interacts with the kinetochore protein CENP-H and delays cell cycle progression.14
229994122013Combined evaluation of centromere protein H and Ki-67 as prognostic biomarker for patients with gastric carcinoma.12
187000422008Prognostic relevance of Centromere protein H expression in esophageal carcinoma.11

Citation

Dessen P

CENPH (centromere protein H)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43644/cenph