CENPI (centromere protein I)

2018-11-01 Affiliation

Identity

HGNC

CENPI

LOCATION

Xq22.1

LOCUSID

2491

ALIAS

CENP-I,FSHPRH1,LRPR1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2491
MIM: 300065
HGNC: 3968
Ensembl: ENSG00000102384

Variants:

dbSNP: 2491
ClinVar: 2491
TCGA: ENSG00000102384
COSMIC: CENPI

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000102384	ENST00000372926	Q92674
ENSG00000102384	ENST00000372927	Q92674
ENSG00000102384	ENST00000372927	A0A024RCG4
ENSG00000102384	ENST00000403304	Q5JX01
ENSG00000102384	ENST00000423383	Q92674
ENSG00000102384	ENST00000423383	A0A024RCG4
ENSG00000102384	ENST00000435570	Q5JX02

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Rho GTPases	REACTOME	R-HSA-194315
RHO GTPase Effectors	REACTOME	R-HSA-195258
RHO GTPases Activate Formins	REACTOME	R-HSA-5663220
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
M Phase	REACTOME	R-HSA-68886
Mitotic Prometaphase	REACTOME	R-HSA-68877
Resolution of Sister Chromatid Cohesion	REACTOME	R-HSA-2500257
Mitotic Metaphase and Anaphase	REACTOME	R-HSA-2555396
Mitotic Anaphase	REACTOME	R-HSA-68882
Separation of Sister Chromatids	REACTOME	R-HSA-2467813
Chromosome Maintenance	REACTOME	R-HSA-73886
Nucleosome assembly	REACTOME	R-HSA-774815
Deposition of new CENPA-containing nucleosomes at the centromere	REACTOME	R-HSA-606279

References

Pubmed ID	Year	Title	Citations
16622420	2006	The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.	195
18045986	2008	KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates.	81
24862574	2014	CENP-I and Aurora B act as a molecular switch that ties RZZ/Mad1 recruitment to kinetochore attachment status.	24
26527398	2015	CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly.	22
25525168	2014	Detection of mutations in LRPAP1, CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2 in 298 families with early-onset high myopia by exome sequencing.	20
29936263	2018	CENPI is overexpressed in colorectal cancer and regulates cell migration and invasion.	2
21888900	2011	Anti-CENPI autoantibodies in scleroderma patients with features of autoimmune liver diseases.	0

Citation

Dessen P

CENPI (centromere protein I)

Atlas Genet Cytogenet Oncol Haematol. 2018-11-01

Online version: http://atlasgeneticsoncology.org/gene/57689/cenpi