CENPU (centromere protein U)

2007-02-01 Affiliation

Identity

HGNC

CENPU

LOCATION

4q35.1

LOCUSID

79682

ALIAS

CENP50,CENPU50,KLIP1,MLF1IP,PBIP1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 79682
MIM: 611511
HGNC: 21348
Ensembl: ENSG00000151725

Variants:

dbSNP: 79682
ClinVar: 79682
TCGA: ENSG00000151725
COSMIC: CENPU

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000151725	ENST00000281453	Q71F23
ENSG00000151725	ENST00000510146	Q09GN1
ENSG00000151725	ENST00000514781	D6R9S4

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Rho GTPases	REACTOME	R-HSA-194315
RHO GTPase Effectors	REACTOME	R-HSA-195258
RHO GTPases Activate Formins	REACTOME	R-HSA-5663220
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
M Phase	REACTOME	R-HSA-68886
Mitotic Prometaphase	REACTOME	R-HSA-68877
Resolution of Sister Chromatid Cohesion	REACTOME	R-HSA-2500257
Mitotic Metaphase and Anaphase	REACTOME	R-HSA-2555396
Mitotic Anaphase	REACTOME	R-HSA-68882
Separation of Sister Chromatids	REACTOME	R-HSA-2467813
Chromosome Maintenance	REACTOME	R-HSA-73886
Nucleosome assembly	REACTOME	R-HSA-774815
Deposition of new CENPA-containing nucleosomes at the centromere	REACTOME	R-HSA-606279

References

Pubmed ID	Year	Title	Citations
17081991	2006	Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation.	115
21056971	2011	CENP-U cooperates with Hec1 to orchestrate kinetochore-microtubule attachment.	27
15116101	2004	cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP.	22
15893739	2005	Regulation of myeloid leukemia factor-1 interacting protein (MLF1IP) expression in glioblastoma.	15
21454580	2011	Mammalian polo-like kinase 1-dependent regulation of the PBIP1-CENP-Q complex at kinetochores.	15
23028590	2012	Step-wise assembly, maturation and dynamic behavior of the human CENP-P/O/R/Q/U kinetochore sub-complex.	14
25572810	2015	MLF1 interacting protein: a potential gene therapy target for human prostate cancer?	8
28677729	2017	Centromere protein U is a potential target for gene therapy of human bladder cancer.	8
27378428	2016	MLF1IP is correlated with progression and prognosis in luminal breast cancer.	7
25670858	2015	Mammalian Polo-like kinase 1 (Plk1) promotes proper chromosome segregation by phosphorylating and delocalizing the PBIP1·CENP-Q complex from kinetochores.	6

Citation

Dessen P

CENPU (centromere protein U)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45740/cenpu