CENPX (centromere protein X)

2016-09-01  

Identity

HGNC
LOCATION
17q25.3
LOCUSID
ALIAS
CENP-X,D9,FAAP10,MHF2,STRA13

Other Information

Locus ID:

NCBI: 201254
MIM: 615128
HGNC: 11422
Ensembl: ENSG00000169689

Variants:

dbSNP: 201254
ClinVar: 201254
TCGA: ENSG00000169689
COSMIC: CENPX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169689ENST00000306704A8MT69
ENSG00000169689ENST00000392359A8MT69
ENSG00000169689ENST00000579520J3QR35
ENSG00000169689ENST00000580435A8MT69
ENSG00000169689ENST00000584347J3QRS1
ENSG00000169689ENST00000584600J3QR01

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Fanconi anemia pathwayKEGGko03460
Fanconi anemia pathwayKEGGhsa03460
Cell CycleREACTOMER-HSA-1640170
Chromosome MaintenanceREACTOMER-HSA-73886
Nucleosome assemblyREACTOMER-HSA-774815
Deposition of new CENPA-containing nucleosomes at the centromereREACTOMER-HSA-606279
DNA RepairREACTOMER-HSA-73894
Fanconi Anemia PathwayREACTOMER-HSA-6783310

References

Pubmed IDYearTitleCitations
203474292010MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM.102
196206312009The CENP-S complex is essential for the stable assembly of outer kinetochore structure.70
204160772010Identification of type 2 diabetes-associated combination of SNPs using support vector machine.26
225106872012The structure of the FANCM-MHF complex reveals physical features for functional assembly.26
243905792014The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes.13
245228852014A CENP-S/X complex assembles at the centromere in S and G2 phases of the human cell cycle.10
88398441996E3, a hematopoietic-specific transcript directly regulated by the retinoic acid receptor alpha.8
242562822013Emerging roles for centromere-associated proteins in DNA repair and genetic recombination.8
246990632014The histone-fold complex MHF is remodeled by FANCM to recognize branched DNA and protect genome stability.8
238867072013Structural peculiarities of the (MHF1-MHF2)4 octamer provide a long DNA binding patch to anchor the MHF-FANCM complex to chromatin: a solution SAXS study.2

Citation

Dessen P

CENPX (centromere protein X)

Atlas Genet Cytogenet Oncol Haematol. 2016-09-01

Online version: http://atlasgeneticsoncology.org/gene/55930/cenpx