CEP152 (centrosomal protein 152)

2014-10-01  

Identity

HGNC
CEP152
LOCATION
15q21.1
LOCUSID
22995
ALIAS
MCPH4,MCPH9,SCKL5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 22995
MIM: 613529
HGNC: 29298
Ensembl: ENSG00000103995

Variants:

dbSNP: 22995
ClinVar: 22995
TCGA: ENSG00000103995
COSMIC: CEP152

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103995ENST00000325747O94986
ENSG00000103995ENST00000380950O94986
ENSG00000103995ENST00000399334O94986
ENSG00000103995ENST00000558591H0YN91
ENSG00000103995ENST00000560322A0A075B719
ENSG00000103995ENST00000561245H0YMG1

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
208526152010Asterless is a scaffold for the onset of centriole assembly.126
210598502010Cep152 interacts with Plk4 and is required for centriole duplication.124
210598442010Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome.119
211319732011CEP152 is a genome maintenance protein disrupted in Seckel syndrome.100
236410732013Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication.81
205982752010Mutations in centrosomal protein CEP152 in primary microcephaly families linked to MCPH4.70
242778142013Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152.69
233333162013Selective chemical crosslinking reveals a Cep57-Cep63-Cep152 centrosomal complex.39
249975972014Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis.35
239361282013Cep63 and cep152 cooperate to ensure centriole duplication.25

Citation

Dessen P

CEP152 (centrosomal protein 152)

Atlas Genet Cytogenet Oncol Haematol. 2014-10-01

Online version: http://atlasgeneticsoncology.org/gene/54930/cep152