CERS4 (ceramide synthase 4)

2015-08-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
LASS4,Trh1
FUSION GENES

Other Information

Locus ID:

NCBI: 79603
MIM: 615334
HGNC: 23747
Ensembl: ENSG00000090661

Variants:

dbSNP: 79603
ClinVar: 79603
TCGA: ENSG00000090661
COSMIC: CERS4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090661ENST00000251363Q9HA82
ENSG00000090661ENST00000558268H0YLY3
ENSG00000090661ENST00000558331H0YKC9
ENSG00000090661ENST00000558877H0YNR6
ENSG00000090661ENST00000559336H0YN04
ENSG00000090661ENST00000559450Q9HA82
ENSG00000090661ENST00000560412H0YKS3
ENSG00000090661ENST00000561008H0YMY6
ENSG00000090661ENST00000561053H0YKR4

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Sphingolipid metabolismKEGGko00600
Sphingolipid metabolismKEGGhsa00600
Metabolic pathwaysKEGGhsa01100
Ceramide biosynthesisKEGGM00094
Sphingosine biosynthesisKEGGM00099
Ceramide biosynthesisKEGGhsa_M00094
Sphingosine biosynthesisKEGGhsa_M00099
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Sphingolipid de novo biosynthesisREACTOMER-HSA-1660661

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
200806502010Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.46
235382982013The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS.17
217574282011Linkage and association of phospholipid transfer protein activity to LASS4.10
268879522016Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region.7
257790242015Linking the ceramide synthases (CerSs) 4 and 5 with apoptosis, endometrial and colon cancers.4
297385502018Genome-wide association meta-analysis of circulating odd-numbered chain saturated fatty acids: Results from the CHARGE Consortium.3

Citation

Dessen P

CERS4 (ceramide synthase 4)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55376/cers4