Identity
HGNC
LOCATION
16q12.2
LOCUSID
ALIAS
ACAT,CE-1,CEH,CES2,HMSE,HMSE1,PCE-1,REH,SES1,TGH,hCE-1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1066
MIM: 114835
HGNC: 1863
Ensembl: ENSG00000198848
Variants:
dbSNP: 1066
ClinVar: 1066
TCGA: ENSG00000198848
COSMIC: CES1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164748728 | mycophenolic acid | Chemical | Pathway | associated | 24220207 | ||
| PA165108401 | Acute coronary syndrome | Disease | ClinicalAnnotation | associated | PD | ||
| PA165110351 | Dabigatran | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PK | PD | 23467860, 27261537 |
| PA165110775 | SN-38 | Chemical | Pathway | associated | |||
| PA166131290 | 2-oxo-clopidogrel | Chemical | VariantAnnotation | associated | 23275066 | ||
| PA443459 | Atrial Fibrillation | Disease | ClinicalAnnotation, VariantAnnotation | associated | PK | PD | 23467860, 27261537 |
| PA443672 | Ischemic Attack, Transient | Disease | ClinicalAnnotation | associated | PD | 27450232 | |
| PA443783 | Constriction, Pathologic | Disease | ClinicalAnnotation | associated | PD | 27450232 | |
| PA443937 | Drug Toxicity | Disease | ClinicalAnnotation | associated | PD | 28139840 | |
| PA447054 | Stroke | Disease | ClinicalAnnotation | associated | PD | 27450232 | |
| PA447197 | Attention Deficit Disorder with Hyperactivity | Disease | ClinicalAnnotation | associated | PK | PD | 19733552 |
| PA448771 | capecitabine | Chemical | ClinicalAnnotation | associated | PD | 28139840 | |
| PA449053 | clopidogrel | Chemical | ClinicalAnnotation, MultilinkAnnotation, VariantAnnotation | associated | PK | PD | 23275066, 24535487, 25704243, 27450232 |
| PA449456 | enalapril | Chemical | ClinicalAnnotation, MultilinkAnnotation | associated | PK | 25919042 | |
| PA450085 | irinotecan | Chemical | Pathway | associated | |||
| PA450464 | methylphenidate | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PK | PD | 19733552 |
| PA450566 | mycophenolate mofetil | Chemical | Pathway | associated | 24220207 | ||
| PA450721 | oseltamivir | Chemical | ClinicalAnnotation, MultilinkAnnotation | ambiguous | PK | 22673926 | |
| PA451205 | quinapril | Chemical | MultilinkAnnotation | not associated | 25919042 | ||
| PA451737 | trandolapril | Chemical | VariantAnnotation | associated | PK | 19185566 | |
| PA452619 | heroin | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PK | 31837295 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37851403 | 2024 | High-Dose Methylphenidate and Carboxylesterase 1 Genetic Variability in Patients With Attention-Deficit/Hyperactivity Disorder: A Case Series. | 0 |
| 37851403 | 2024 | High-Dose Methylphenidate and Carboxylesterase 1 Genetic Variability in Patients With Attention-Deficit/Hyperactivity Disorder: A Case Series. | 0 |
| 36413357 | 2023 | Identification of regulatory variants of carboxylesterase 1 (CES1): A proof-of-concept study for the application of the Allele-Specific Protein Expression (ASPE) assay in identifying cis-acting regulatory genetic polymorphisms. | 2 |
| 37372371 | 2023 | The Distribution of the Genotypes of ABCB1 and CES1 Polymorphisms in Kazakhstani Patients with Atrial Fibrillation Treated with DOAC. | 2 |
| 36413357 | 2023 | Identification of regulatory variants of carboxylesterase 1 (CES1): A proof-of-concept study for the application of the Allele-Specific Protein Expression (ASPE) assay in identifying cis-acting regulatory genetic polymorphisms. | 2 |
| 37372371 | 2023 | The Distribution of the Genotypes of ABCB1 and CES1 Polymorphisms in Kazakhstani Patients with Atrial Fibrillation Treated with DOAC. | 2 |
| 34633041 | 2022 | Carboxylesterase-1 Assisted Targeting of HDAC Inhibitors to Mononuclear Myeloid Cells in Inflammatory Bowel Disease. | 7 |
| 34697082 | 2022 | Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms. | 1 |
| 35459739 | 2022 | Adipose tissue-specific ablation of Ces1d causes metabolic dysregulation in mice. | 11 |
| 36553492 | 2022 | The Influence of Structural Variants of the CES1 Gene on the Pharmacokinetics of Enalapril, Presumably Due to Linkage Disequilibrium with the Intronic rs2244613. | 1 |
| 34633041 | 2022 | Carboxylesterase-1 Assisted Targeting of HDAC Inhibitors to Mononuclear Myeloid Cells in Inflammatory Bowel Disease. | 7 |
| 34697082 | 2022 | Transcriptional Regulation of Carboxylesterase 1 in Human Liver: Role of the Nuclear Receptor Subfamily 1 Group H Member 3 and Its Splice Isoforms. | 1 |
| 35459739 | 2022 | Adipose tissue-specific ablation of Ces1d causes metabolic dysregulation in mice. | 11 |
| 36553492 | 2022 | The Influence of Structural Variants of the CES1 Gene on the Pharmacokinetics of Enalapril, Presumably Due to Linkage Disequilibrium with the Intronic rs2244613. | 1 |
| 33791812 | 2021 | Clock gene Bmal1 controls diurnal rhythms in expression and activity of intestinal carboxylesterase 1. | 3 |
Citation
Dessen P
CES1 (carboxylesterase 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/40060/ces1
