CGB3 (chorionic gonadotropin subunit beta 3)

2016-01-01  

Identity

HGNC
LOCATION
19q13.33
LOCUSID
ALIAS
CGB,CGB5,CGB7,CGB8,LHB,hCGB

Other Information

Locus ID:

NCBI: 1082
MIM: 118860
HGNC: 1886
Ensembl: ENSG00000104827

Variants:

dbSNP: 1082
ClinVar: 1082
TCGA: ENSG00000104827
COSMIC: CGB3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104827ENST00000357383P0DN86
ENSG00000104827ENST00000357383A0A0F7RQP8

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Peptide hormone biosynthesisREACTOMER-HSA-209952
Glycoprotein hormonesREACTOMER-HSA-209822
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsREACTOMER-HSA-8864260
TFAP2 (AP-2) family regulates transcription of growth factors and their receptorsREACTOMER-HSA-8866910

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
257077402015Review: hCGs: different sources of production, different glycoforms and functions.30
200651112010TCR mimic monoclonal antibody targets a specific peptide/HLA class I complex and significantly impedes tumor growth in vivo using breast cancer models.22
206546922010Does hCG or hCGβ play a role in cancer cell biology?21
213886782011Villous trophoblast abnormalities in extremely preterm deliveries with elevated second trimester maternal serum hCG or inhibin-A.14
234246162013Human chorionic gonadotropin β induces migration and invasion via activating ERK1/2 and MMP-2 in human prostate cancer DU145 cells.14
121751532002Enhanced affinity capture MALDI-TOF MS: orientation of an immunoglobulin G using recombinant protein G.13
180484582008Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues.13
192908442009Effect of maternal smoking on cord blood estriol, placental lactogen, chorionic gonadotropin, FSH, LH, and cortisol.13
160071232005Fetal but not adult Leydig cells are susceptible to adenoma formation in response to persistently high hCG level: a study on hCG overexpressing transgenic mice.12
185779952008Alpha-fetoprotein and human chorionic gonadotrophin-beta as prognostic markers in neuroendocrine tumour patients.12

Citation

Dessen P

CGB3 (chorionic gonadotropin subunit beta 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-01-01

Online version: http://atlasgeneticsoncology.org/gene/55594/cgb3