CHAF1A (chromatin assembly factor 1 subunit A)

2003-12-01  

Identity

HGNC
CHAF1A
LOCATION
19p13.3
LOCUSID
10036
ALIAS
CAF-1,CAF1,CAF1B,CAF1P150,P150
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10036
MIM: 601246
HGNC: 1910
Ensembl: ENSG00000167670

Variants:

dbSNP: 10036
ClinVar: 10036
TCGA: ENSG00000167670
COSMIC: CHAF1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167670ENST00000301280Q13111
ENSG00000167670ENST00000585371K7ENC7
ENSG00000167670ENST00000585854K7EJF1
ENSG00000167670ENST00000587739K7EPA1
ENSG00000167670ENST00000589648K7EME9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
150673242004Gene expression profiling predicts clinical outcome of prostate cancer.171
170996992006The chromatin-remodeling enzyme ACF is an ATP-dependent DNA length sensor that regulates nucleosome spacing.101
185595512008Pathway analysis of single-nucleotide polymorphisms potentially associated with glioblastoma multiforme susceptibility using random forests.44
198226592009Two fundamentally distinct PCNA interaction peptides contribute to chromatin assembly factor 1 function.36
212826222011CAF-I-dependent control of degradation of the discontinuous strands during mismatch repair.36
272692842016Nucleosome disassembly during human non-homologous end joining followed by concerted HIRA- and CAF-1-dependent reassembly.29
168262392006The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin assembly factor 1 with proliferating cell nuclear antigen.28
182703392008Comprehensive analysis of DNA repair gene variants and risk of meningioma.22
243359602014Histone chaperone CHAF1A inhibits differentiation and promotes aggressive neuroblastoma.18
295331812018NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins.15

Citation

Dessen P

CHAF1A (chromatin assembly factor 1 subunit A)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/40067/chaf1a