CHD4 (chromodomain helicase DNA binding protein 4)

2003-05-01  

Identity

HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
CHD-4,Mi-2b,Mi2-BETA,SIHIWES
FUSION GENES

Other Information

Locus ID:

NCBI: 1108
MIM: 603277
HGNC: 1919
Ensembl: ENSG00000111642

Variants:

dbSNP: 1108
ClinVar: 1108
TCGA: ENSG00000111642
COSMIC: CHD4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111642ENST00000357008A0A2U3TZM0
ENSG00000111642ENST00000544040Q14839
ENSG00000111642ENST00000544484A0A0C4DGG9
ENSG00000111642ENST00000545584F5H596
ENSG00000111642ENST00000545942F5H6N4
ENSG00000111642ENST00000642594A0A2R8Y425
ENSG00000111642ENST00000642637A0A2R8YE38
ENSG00000111642ENST00000642810A0A2R8Y5Z7
ENSG00000111642ENST00000642879A0A2R8Y521
ENSG00000111642ENST00000642893A0A2R8Y512
ENSG00000111642ENST00000643335A0A2R8YFD8
ENSG00000111642ENST00000643538A0A2R8Y5M9
ENSG00000111642ENST00000643815A0A2R8YD40
ENSG00000111642ENST00000644077A0A2R8Y7M9
ENSG00000111642ENST00000644132A0A2R8Y539
ENSG00000111642ENST00000644137A0A2R8YER1
ENSG00000111642ENST00000644289A0A2R8Y8C1
ENSG00000111642ENST00000644352A0A2R8YDW2
ENSG00000111642ENST00000644652A0A2R8Y6G9
ENSG00000111642ENST00000644801A0A2R8Y8B3
ENSG00000111642ENST00000645005A0A2R8Y212
ENSG00000111642ENST00000645022F5GWX5
ENSG00000111642ENST00000645095Q14839
ENSG00000111642ENST00000645143A0A2R8Y795
ENSG00000111642ENST00000645645A0A2R8YFK9
ENSG00000111642ENST00000645991A0A2R8Y7X1
ENSG00000111642ENST00000646268A0A2R8Y685
ENSG00000111642ENST00000646462A0A2R8Y7I0
ENSG00000111642ENST00000646608A0A2R8YDJ9
ENSG00000111642ENST00000646806A0A2R8Y5J0
ENSG00000111642ENST00000647483A0A2R8Y4X2

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase I TranscriptionREACTOMER-HSA-73864
RNA Polymerase I Promoter ClearanceREACTOMER-HSA-73854
RNA Polymerase I Transcription InitiationREACTOMER-HSA-73762
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDACs deacetylate histonesREACTOMER-HSA-3214815
Positive epigenetic regulation of rRNA expressionREACTOMER-HSA-5250913
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through AcetylationREACTOMER-HSA-6804758
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expressionREACTOMER-HSA-427389

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164748224vorinostatChemicalMultilinkAnnotationassociated26296641

References

Pubmed IDYearTitleCitations
176940842007The human Mi-2/NuRD complex and gene regulation.214
274799072016Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing.73
212782512011Plant homeodomain (PHD) fingers of CHD4 are histone H3-binding modules with preference for unmodified H3K4 and methylated H3K9.72
196242892009Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications.59
237086672014The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes.41
257372782015Resistance to therapy in BRCA2 mutant cells due to loss of the nucleosome remodeling factor CHD4.41
249919572014Promoter decommissioning by the NuRD chromatin remodeling complex triggers synaptic connectivity in the mammalian brain.40
284861052017CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes.39
225758882012The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4.31
145302592003Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities.29

Citation

Dessen P

CHD4 (chromodomain helicase DNA binding protein 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40072/chd4