CHGA (chromogranin A)

2003-08-01  

Identity

HGNC
CHGA
LOCATION
14q32.12
LOCUSID
1113
ALIAS
CGA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1113
MIM: 118910
HGNC: 1929
Ensembl: ENSG00000100604

Variants:

dbSNP: 1113
ClinVar: 1113
TCGA: ENSG00000100604
COSMIC: CHGA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100604ENST00000216492P10645
ENSG00000100604ENST00000334654G5E968
ENSG00000100604ENST00000556076G3V2Q7

Expression (GTEx)

0
100
200
300
400
500
600
700
800
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Antimicrobial peptidesREACTOMER-HSA-6803157

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
160072572005Hypertension from targeted ablation of chromogranin A can be rescued by the human ortholog.99
219949542011Chromogranin A and neuron-specific enolase as prognostic markers in patients with advanced pNET treated with everolimus.51
174381542007Catecholamine release-inhibitory peptide catestatin (chromogranin A(352-372)): naturally occurring amino acid variant Gly364Ser causes profound changes in human autonomic activity and alters risk for hypertension.42
174381542007Catecholamine release-inhibitory peptide catestatin (chromogranin A(352-372)): naturally occurring amino acid variant Gly364Ser causes profound changes in human autonomic activity and alters risk for hypertension.42
213494142011The clinical relevance of chromogranin A as a biomarker for gastroenteropancreatic neuroendocrine tumors.40
190581392009Oct4A is expressed by a subpopulation of prostate neuroendocrine cells.30
190905602009Plasma chromogranin a in patients with inflammatory bowel disease.30
198552342009Biochemical testing for neuroendocrine tumors.30
242390022014Chromogranin A is a T cell antigen in human type 1 diabetes.30
155428602005Role of H+-ATPase-mediated acidification in sorting and release of the regulated secretory protein chromogranin A: evidence for a vesiculogenic function.29

Citation

Dessen P

CHGA (chromogranin A)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40074/chga