CHI3L2 (chitinase 3 like 2)

2012-10-01  

Identity

HGNC
CHI3L2
LOCATION
1p13.2
LOCUSID
1117
ALIAS
CHIL2,YKL-39,YKL39
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1117
MIM: 601526
HGNC: 1933
Ensembl: ENSG00000064886

Variants:

dbSNP: 1117
ClinVar: 1117
TCGA: ENSG00000064886
COSMIC: CHI3L2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000064886ENST00000369744Q15782
ENSG00000064886ENST00000369748Q15782
ENSG00000064886ENST00000445067Q15782
ENSG00000064886ENST00000466741Q15782
ENSG00000064886ENST00000467038E9PII8
ENSG00000064886ENST00000472825H0YEJ1
ENSG00000064886ENST00000474304E9PP75
ENSG00000064886ENST00000477185E9PPX4
ENSG00000064886ENST00000486561E9PIX1
ENSG00000064886ENST00000497220H0YE91
ENSG00000064886ENST00000497587E9PRL9
ENSG00000064886ENST00000524472Q15782
ENSG00000064886ENST00000528451E9PR52
ENSG00000064886ENST00000533831H0YD88

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
cartilage
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
124353962002Enhanced expression of the human chitinase 3-like 2 gene (YKL-39) but not chitinase 3-like 1 gene (YKL-40) in osteoarthritic cartilage.26
256981712015Chitinase 3-like proteins as diagnostic and prognostic biomarkers of multiple sclerosis.24
222111032012Two closely related human members of chitinase-like family, CHI3L1 and CHI3L2, activate ERK1/2 in 293 and U373 cells but have the different influence on cell proliferation.17
267331602016Role of chitinase-like proteins in cancer.17
227424502012Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide-binding properties.15
254775132015Structural and thermodynamic insights into chitooligosaccharide binding to human cartilage chitinase 3-like protein 2 (CHI3L2 or YKL-39).7
289890022017CHI3L1 and CHI3L2 overexpression in motor cortex and spinal cord of sALS patients.7
276538982016Chitinase expression in Alzheimer's disease and non-demented brains regions.5
297287992018Expression of M2 macrophage markers YKL-39 and CCL18 in breast cancer is associated with the effect of neoadjuvant chemotherapy.5

Citation

Dessen P

CHI3L2 (chitinase 3 like 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-10-01

Online version: http://atlasgeneticsoncology.org/gene/52915/chi3l2