CHPF (chondroitin polymerizing factor)

2011-08-01  

Identity

HGNC
LOCATION
2q35
LOCUSID
ALIAS
CHSY2,CSS2

Other Information

Locus ID:

NCBI: 79586
MIM: 610405
HGNC: 24291
Ensembl: ENSG00000123989

Variants:

dbSNP: 79586
ClinVar: 79586
TCGA: ENSG00000123989
COSMIC: CHPF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123989ENST00000243776Q8IZ52
ENSG00000123989ENST00000373891F8W6H2
ENSG00000123989ENST00000535926Q8IZ52

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfateKEGGko00532
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfateKEGGhsa00532
Metabolic pathwaysKEGGhsa01100
Glycosaminoglycan biosynthesis, chondroitin sulfate backboneKEGGhsa_M00058
Glycosaminoglycan biosynthesis, chondroitin sulfate backboneKEGGM00058
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Chondroitin sulfate/dermatan sulfate metabolismREACTOMER-HSA-1793185
Chondroitin sulfate biosynthesisREACTOMER-HSA-2022870

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
127168902003Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization.40
224619102012FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma.27
214685782011Chondroitin synthases I, II, III and chondroitin sulfate glucuronyltransferase expression in colorectal cancer.12
220828302012Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential.6
286277022017Lentivirus‑mediated knockdown of chondroitin polymerizing factor inhibits glioma cell growth in vitro.6
207295472010Chondroitin sulfate synthase-2/chondroitin polymerizing factor has two variants with distinct function.5
286089412018TGF-β Stimulates Expression of Chondroitin Polymerizing Factor in Nucleus Pulposus Cells Through the Smad3, RhoA/ROCK1, and MAPK Signaling Pathways.4
308261522019CHPF promotes lung adenocarcinoma proliferation and anti-apoptosis via the MAPK pathway.1

Citation

Dessen P

CHPF (chondroitin polymerizing factor)

Atlas Genet Cytogenet Oncol Haematol. 2011-08-01

Online version: http://atlasgeneticsoncology.org/gene/52317/chpf