Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1138
MIM: 118505
HGNC: 1959
Ensembl: ENSG00000169684
Variants:
dbSNP: 1138
ClinVar: 1138
TCGA: ENSG00000169684
COSMIC: CHRNA5
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000169684 | ENST00000299565 | P30532 |
| ENSG00000169684 | ENST00000394802 | H7BYM0 |
| ENSG00000169684 | ENST00000559554 | H0YM98 |
| ENSG00000169684 | ENST00000559576 | H0YK34 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164712720 | Drugs used in nicotine dependence | Chemical | ClinicalAnnotation | associated | PD | 25950378 | |
| PA164712950 | Opium alkaloids and derivatives | Chemical | ClinicalAnnotation | associated | PD | 20725741 | |
| PA164781343 | varenicline | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 25950378 | |
| PA166114414 | cotinine | Chemical | ClinicalAnnotation | associated | PK | PD | |
| PA443309 | Alcoholism | Disease | ClinicalAnnotation | associated | PD | ||
| PA445208 | Pain | Disease | ClinicalAnnotation | associated | PD | 20725741 | |
| PA445876 | Tobacco Use Disorder | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PK | PD | 20725741, 20886544, 25950378, 27355804 |
| PA446878 | Cocaine-Related Disorders | Disease | ClinicalAnnotation | associated | PD | 32152934 | |
| PA448073 | ethanol | Chemical | ClinicalAnnotation | associated | PD | ||
| PA448687 | bupropion | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 25950378 | |
| PA449072 | cocaine | Chemical | ClinicalAnnotation | associated | PD | 32152934 | |
| PA450626 | nicotine | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 20725741, 20886544, 25950378, 27355804, 31402126 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37921560 | 2024 | PLEK2 mediates metastasis and invasion via α5-nAChR activation in nicotine-induced lung adenocarcinoma. | 1 |
| 38331937 | 2024 | CHRNA5 links chandelier cells to severity of amyloid pathology in aging and Alzheimer's disease. | 0 |
| 37921560 | 2024 | PLEK2 mediates metastasis and invasion via α5-nAChR activation in nicotine-induced lung adenocarcinoma. | 1 |
| 38331937 | 2024 | CHRNA5 links chandelier cells to severity of amyloid pathology in aging and Alzheimer's disease. | 0 |
| 37116611 | 2023 | CHRNA5 gene variation affects the response of VTA dopaminergic neurons during chronic nicotine exposure and withdrawal. | 1 |
| 37372959 | 2023 | The rs16969968 Tobacco Smoking-Related Single-Nucleotide Variant Is Associated with Clinical Markers in Patients with Severe COVID-19. | 1 |
| 37116611 | 2023 | CHRNA5 gene variation affects the response of VTA dopaminergic neurons during chronic nicotine exposure and withdrawal. | 1 |
| 37372959 | 2023 | The rs16969968 Tobacco Smoking-Related Single-Nucleotide Variant Is Associated with Clinical Markers in Patients with Severe COVID-19. | 1 |
| 34994389 | 2022 | α5-nAChR associated with Ly6E modulates cell migration via TGF-β1/Smad signaling in non-small cell lung cancer. | 8 |
| 35513071 | 2022 | CHRNA5 Is Overexpressed in Patients with Psoriasis and Promotes Psoriasis-Like Inflammation in Mouse Models. | 4 |
| 36078193 | 2022 | Association of Polymorphism CHRNA5 and CHRNA3 Gene in People Addicted to Nicotine. | 3 |
| 36230899 | 2022 | The Nicotinic Receptor Polymorphism rs16969968 Is Associated with Airway Remodeling and Inflammatory Dysregulation in COPD Patients. | 2 |
| 34994389 | 2022 | α5-nAChR associated with Ly6E modulates cell migration via TGF-β1/Smad signaling in non-small cell lung cancer. | 8 |
| 35513071 | 2022 | CHRNA5 Is Overexpressed in Patients with Psoriasis and Promotes Psoriasis-Like Inflammation in Mouse Models. | 4 |
| 36078193 | 2022 | Association of Polymorphism CHRNA5 and CHRNA3 Gene in People Addicted to Nicotine. | 3 |
Citation
Dessen P
CHRNA5 (cholinergic receptor nicotinic alpha 5 subunit)
Atlas Genet Cytogenet Oncol Haematol. 2008-05-01
Online version: http://atlasgeneticsoncology.org/gene/50146/chrna5
