Identity
HGNC
LOCATION
15q13.2
LOCUSID
ALIAS
CHRNA7-2,NACHRA7
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1139
MIM: 118511
HGNC: 1960
Ensembl: ENSG00000175344
Variants:
dbSNP: 1139
ClinVar: 1139
TCGA: ENSG00000175344
COSMIC: CHRNA7
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443319 | Alzheimer Disease | Disease | ClinicalAnnotation | associated | PD | 24951635 | |
| PA449394 | donepezil | Chemical | ClinicalAnnotation | associated | PD | 24951635 | |
| PA449726 | galantamine | Chemical | ClinicalAnnotation | associated | PD | 24951635 | |
| PA450626 | nicotine | Chemical | ClinicalAnnotation | associated | PD | 20231857 | |
| PA451262 | rivastigmine | Chemical | ClinicalAnnotation | associated | PD | 24951635 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37640915 | 2024 | Regulation of Inflammation by IRAK-M Pathway Can Be Associated with nAchRalpha7 Activation and COVID-19. | 2 |
| 38836054 | 2024 | The human alpha7 nicotinic acetylcholine receptor is a host target for the rabies virus glycoprotein. | 0 |
| 37640915 | 2024 | Regulation of Inflammation by IRAK-M Pathway Can Be Associated with nAchRalpha7 Activation and COVID-19. | 2 |
| 38836054 | 2024 | The human alpha7 nicotinic acetylcholine receptor is a host target for the rabies virus glycoprotein. | 0 |
| 36604774 | 2023 | The holistic approach to the CHRNA7 gene, hsa-miR-3158-5p, and 15q13.3 hotspot CNVs in migraineurs. | 3 |
| 36966906 | 2023 | α7 Nicotinic acetylcholine receptor potentiation downregulates chemotherapy-induced inflammatory overactivation by overlapping intracellular mechanisms. | 0 |
| 36972659 | 2023 | α7 Nicotinic acetylcholine receptors regulate translocation of HIF-1α to the cell nucleus and mitochondria upon hypoxia. | 0 |
| 36973813 | 2023 | α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect. | 7 |
| 37295770 | 2023 | Epstein-Barr virus downregulates the α7 nicotinic acetylcholine receptor of CD8(+) T lymphocytes might associate with coronary artery lesions in Kawasaki disease patients. | 0 |
| 37804592 | 2023 | Crystal structure reveals canonical recognition of the phosphorylated cytoplasmic loop of human alpha7 nicotinic acetylcholine receptor by 14-3-3 protein. | 0 |
| 36604774 | 2023 | The holistic approach to the CHRNA7 gene, hsa-miR-3158-5p, and 15q13.3 hotspot CNVs in migraineurs. | 3 |
| 36966906 | 2023 | α7 Nicotinic acetylcholine receptor potentiation downregulates chemotherapy-induced inflammatory overactivation by overlapping intracellular mechanisms. | 0 |
| 36972659 | 2023 | α7 Nicotinic acetylcholine receptors regulate translocation of HIF-1α to the cell nucleus and mitochondria upon hypoxia. | 0 |
| 36973813 | 2023 | α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect. | 7 |
| 37295770 | 2023 | Epstein-Barr virus downregulates the α7 nicotinic acetylcholine receptor of CD8(+) T lymphocytes might associate with coronary artery lesions in Kawasaki disease patients. | 0 |
Citation
Dessen P
CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45735/chrna7
