CHRNA9 (cholinergic receptor nicotinic alpha 9 subunit)

2010-10-01  

Identity

HGNC
LOCATION
4p14
LOCUSID
ALIAS
HSA243342,NACHRA9
FUSION GENES

Other Information

Locus ID:

NCBI: 55584
MIM: 605116
HGNC: 14079
Ensembl: ENSG00000174343

Variants:

dbSNP: 55584
ClinVar: 55584
TCGA: ENSG00000174343
COSMIC: CHRNA9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174343ENST00000310169Q9UGM1

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Acetylcholine Binding And Downstream EventsREACTOMER-HSA-181431
Activation of Nicotinic Acetylcholine ReceptorsREACTOMER-HSA-629602
Postsynaptic nicotinic acetylcholine receptorsREACTOMER-HSA-622327
Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsREACTOMER-HSA-629594

References

Pubmed IDYearTitleCitations
192599742009Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.121
163148712006Why do young women smoke? I. Direct and interactive effects of environment, psychological characteristics and nicotinic cholinergic receptor genes.56
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
207331182010Overexpression and activation of the alpha9-nicotinic receptor during tumorigenesis in human breast epithelial cells.44
282235282017Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain.40
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
227748722012Molecular basis for the differential sensitivity of rat and human α9α10 nAChRs to α-conotoxin RgIA.35
202291772011Nicotine-induced human breast cancer cell proliferation attenuated by garcinol through down-regulation of the nicotinic receptor and cyclin D3 proteins.33
177061942007Central role of alpha9 acetylcholine receptor in coordinating keratinocyte adhesion and motility at the initiation of epithelialization.28
273492882016Phosphocholine - an agonist of metabotropic but not of ionotropic functions of α9-containing nicotinic acetylcholine receptors.27

Citation

Dessen P

CHRNA9 (cholinergic receptor nicotinic alpha 9 subunit)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51743/chrna9