Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1143
MIM: 118509
HGNC: 1964
Ensembl: ENSG00000117971
Variants:
dbSNP: 1143
ClinVar: 1143
TCGA: ENSG00000117971
COSMIC: CHRNB4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000117971 | ENST00000261751 | P30926 |
| ENSG00000117971 | ENST00000412074 | P30926 |
| ENSG00000117971 | ENST00000559849 | H3BU02 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166114414 | cotinine | Chemical | ClinicalAnnotation | associated | PK | ||
| PA445876 | Tobacco Use Disorder | Disease | ClinicalAnnotation, VariantAnnotation | associated | PK | PD | 20886544 |
| PA450626 | nicotine | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 20886544 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33578531 | 2021 | The relationship between CHRNA5/A3/B4 gene cluster polymorphisms and lung cancer risk: An updated meta-analysis and systematic review. | 3 |
| 33578531 | 2021 | The relationship between CHRNA5/A3/B4 gene cluster polymorphisms and lung cancer risk: An updated meta-analysis and systematic review. | 3 |
| 29971594 | 2018 | Genetic modifiers of radon-induced lung cancer risk: a genome-wide interaction study in former uranium miners. | 14 |
| 30453884 | 2018 | Combined genetic influence of the nicotinic receptor gene cluster CHRNA5/A3/B4 on nicotine dependence. | 9 |
| 29971594 | 2018 | Genetic modifiers of radon-induced lung cancer risk: a genome-wide interaction study in former uranium miners. | 14 |
| 30453884 | 2018 | Combined genetic influence of the nicotinic receptor gene cluster CHRNA5/A3/B4 on nicotine dependence. | 9 |
| 27758088 | 2017 | The CHRNA5/CHRNA3/CHRNB4 Nicotinic Receptor Regulome: Genomic Architecture, Regulatory Variants, and Clinical Associations. | 13 |
| 27758088 | 2017 | The CHRNA5/CHRNA3/CHRNB4 Nicotinic Receptor Regulome: Genomic Architecture, Regulatory Variants, and Clinical Associations. | 13 |
| 25471942 | 2016 | Contribution of Variants in CHRNA5/A3/B4 Gene Cluster on Chromosome 15 to Tobacco Smoking: From Genetic Association to Mechanism. | 33 |
| 26689306 | 2016 | Gene variance in the nicotinic receptor cluster (CHRNA5-CHRNA3-CHRNB4) predicts death from cardiopulmonary disease and cancer in smokers. | 14 |
| 26904947 | 2016 | MafA-Controlled Nicotinic Receptor Expression Is Essential for Insulin Secretion and Is Impaired in Patients with Type 2 Diabetes. | 18 |
| 26942719 | 2016 | Chromosome 15q25 (CHRNA3-CHRNB4) Variation Indirectly Impacts Lung Cancer Risk in Chinese Males. | 5 |
| 27302872 | 2016 | Pleiotropic effects of Chr15q25 nicotinic gene cluster and the relationship between smoking, cognition and ADHD. | 6 |
| 25471942 | 2016 | Contribution of Variants in CHRNA5/A3/B4 Gene Cluster on Chromosome 15 to Tobacco Smoking: From Genetic Association to Mechanism. | 33 |
| 26689306 | 2016 | Gene variance in the nicotinic receptor cluster (CHRNA5-CHRNA3-CHRNB4) predicts death from cardiopulmonary disease and cancer in smokers. | 14 |
Citation
Dessen P
CHRNB4 (cholinergic receptor nicotinic beta 4 subunit)
Atlas Genet Cytogenet Oncol Haematol. 2011-06-01
Online version: http://atlasgeneticsoncology.org/gene/52258/chrnb4
