CHTF18 (chromosome transmission fidelity factor 18)

2007-04-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
C16orf41,C321D2.2,C321D2.3,C321D2.4,CHL12,Ctf18,RUVBL
FUSION GENES

Other Information

Locus ID:

NCBI: 63922
MIM: 613201
HGNC: 18435
Ensembl: ENSG00000127586

Variants:

dbSNP: 63922
ClinVar: 63922
TCGA: ENSG00000127586
COSMIC: CHTF18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127586ENST00000262315Q8WVB6
ENSG00000127586ENST00000317063E7EXA6
ENSG00000127586ENST00000426047H0Y7D3
ENSG00000127586ENST00000440239F8WCC1
ENSG00000127586ENST00000455171Q8WVB6
ENSG00000127586ENST00000563545H3BT35
ENSG00000127586ENST00000569270H3BN43
ENSG00000127586ENST00000631357A0A0D9SF58

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

References

Pubmed IDYearTitleCitations
129309022003The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA.58
184996582008Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1.41
121719292002A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.28
127661762003Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment.24
208267852010Stable interaction between the human proliferating cell nuclear antigen loader complex Ctf18-replication factor C (RFC) and DNA polymerase {epsilon} is mediated by the cohesion-specific subunits, Ctf18, Dcc1, and Ctf8.21
237551032014Sequencing of candidate chromosome instability genes in endometrial cancers reveals somatic mutations in ESCO1, CHTF18, and MRE11A.15
175451662007A second proliferating cell nuclear antigen loader complex, Ctf18-replication factor C, stimulates DNA polymerase eta activity.12
281996902017Human CTF18-RFC clamp-loader complexed with non-synthesising DNA polymerase ε efficiently loads the PCNA sliding clamp.3
271756162016CTF18 interacts with replication protein A in response to replication stress.0

Citation

Dessen P

CHTF18 (chromosome transmission fidelity factor 18)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46708/chtf18