CIDEC (cell death inducing DFFA like effector c)

2012-09-01 Affiliation

Identity

HGNC

CIDEC

LOCATION

3p25.3

LOCUSID

63924

ALIAS

CIDE-3,CIDE3,FPLD5,FSP27

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 63924
MIM: 612120
HGNC: 24229
Ensembl: ENSG00000187288

Variants:

dbSNP: 63924
ClinVar: 63924
TCGA: ENSG00000187288
COSMIC: CIDEC

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000187288	ENST00000336832	Q96AQ7
ENSG00000187288	ENST00000336832	A0A024R2F7
ENSG00000187288	ENST00000383817	A0A0A0MRY9
ENSG00000187288	ENST00000423850	Q96AQ7
ENSG00000187288	ENST00000430427	Q96AQ7
ENSG00000187288	ENST00000443115	A0A0C4DG75
ENSG00000187288	ENST00000455015	Q96AQ7
ENSG00000187288	ENST00000618572	Q96AQ7

Expression (GTEx)

100

200

300

400

500

600

700

800

900

1000

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Lipid digestion, mobilization, and transport	REACTOME	R-HSA-73923
Lipoprotein metabolism	REACTOME	R-HSA-174824
Chylomicron-mediated lipid transport	REACTOME	R-HSA-174800

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
18334488	2008	Fat-specific protein 27 regulates storage of triacylglycerol.	84
20049731	2009	Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC.	79
26099526	2015	Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans.	44
12429024	2003	Molecular cloning and characterization of CIDE-3, a novel member of the cell-death-inducing DNA-fragmentation-factor (DFF45)-like effector family.	37
24627478	2014	Fat-specific protein 27 (FSP27) interacts with adipose triglyceride lipase (ATGL) to regulate lipolysis and insulin sensitivity in human adipocytes.	37
20089860	2010	Fat-specific protein 27 undergoes ubiquitin-dependent degradation regulated by triacylglycerol synthesis and lipid droplet formation.	30
23233732	2013	Fat-specific protein 27 modulates nuclear factor of activated T cells 5 and the cellular response to stress.	21
18702959	2008	Cell death-inducing DFF45-like effector C is reduced by caloric restriction and regulates adipocyte lipid metabolism.	20
19661960	2010	Hepatic expression of cell death-inducing DFFA-like effector C in obese subjects is reduced by marked weight loss.	16
23220584	2013	Fsp27/CIDEC is a CREB target gene induced during early fasting in liver and regulated by FA oxidation rate.	16

Citation

Dessen P

CIDEC (cell death inducing DFFA like effector c)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52868/cidec